Acne Supplements Sold Online

Acne Supplements Sold Online

Authors

  • Emily Burns Baylor College of Medicine, Houston, TX, USA
  • Milbrey Parke Baylor College of Medicine, Houston, TX, USA
  • Ariadna Perez-Sanchez Department of Internal Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
  • Dina Zamil Baylor College of Medicine, Houston, TX, USA
  • Rajani Katta Department of Dermatology, McGovern Medical School at University of Texas Health Science Center at Houston, Houston, TX, USA

Keywords:

acne supplement, dietary supplement, diet, nutrition, safety

Abstract

Introduction: As no centralized database of acne supplements is available, we aimed to provide an overview of these products, with a focus on safety.

Objectives: The objectives of this study were to document the number, formulation, contents, and marketing strategies utilized by acne supplements sold online.

Methods: An online search was conducted between March and May 2020. Products were included in the study if they used the terms: “whitehead”, “blackhead”, or “acne”. Data were extracted from the website, box, and Supplement Facts label.

Results: 49 products were identified, which contained 146 unique ingredients. These included vitamins, minerals, food extracts, botanical extracts, amino acids, animal products, and distinct microbial strains. Few (4.1%) products were tested by third parties.

Conclusions: This survey of acne supplements available online raised concerns regarding lack of warning labels, teratogenicity, exceedingly large levels of vitamins and minerals, and lack of third-party testing. Given the limited regulation and oversight of dietary supplements, it is imperative that physicians educate patients on the potential risks of these products.

References

Chen F, Du M, Blumberg JB, et al. Association Between Dietary Supplement Use, Nutrient Intake, and Mortality Among US Adults: A Cohort Study. Ann Intern Med. 2019;170(9):604-613. DOI: 10.7326/M18-2478. PMID: 30959527; PMCID: PMC6736694. 2. Bickers DR, Lim HW, Margolis D, et al. The burden of skin diseases: 2004. J Am Acad Dermatol. 2006;55:490–500. DOI: 10.1016/j.jaad.2006.05.048. PMID: 16908356.

White GM. Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J Am Acad Dermatol. 1998;39:S34–37. DOI: 10.1016/S0190-9622(98)70442-6. PMID: 9703121.

Dall'Oglio F, Nasca MR, Fiorentini F, Micali G. Diet and acne: review of the evidence from 2009 to 2020. Int J Dermatol. 2021;60(6):672-685. DOI: 10.1111/ijd.15390. PMID: 33462816.

Bowe WP, Joshi SS, Shalita AR. Diet and acne. J Am Acad Dermatol. 2010; 63(1):124-141. DOI: 10.1016/j.jaad.2009.07.043. PMID: 20338665.

Dreno B, Moyse D, Alirezai M, et al. Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris. Dermatol Basel Switz. 2001;203:135–140. DOI: 10.1159/000051728. PMID: 11586012.

Katta R, Kramer MJ. Skin and Diet: An Update on the Role of Dietary Change as a Treatment Strategy for Skin Disease. Skin Ther Lett. 2018;23:1–5. PMID: 29357214.

Michaëlsson G, Edqvist LE. Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment. Acta Derm Venereol. 1984;64:9–14. PMID: 6203294.

Michaëlsson G. Decreased concentration of selenium in whole blood and plasma in acne vulgaris. Acta Derm Venereol. 1990;70:92. PMID: 1967890.

El-Akawi Z, Abdel-Latif N, Abdul-Razzak K. Does the plasma level of vitamins A and E affect acne condition? Clin Exp Dermatol. 2006;31:430–434. DOI: 10.1111/j.1365-2230.2006.02106.x. PMID: 16681594.

Liao S. The medicinal action of androgens and green tea epigallocatechin gallate. Hong Kong Med J Xianggang Yi Xue Za Zhi. 2001;7:369–374. PMID: 11773671.

Sato T, Takahashi A, Kojima M, Akimoto N, Yano M, Ito A. A citrus polymethoxy flavonoid, nobiletin inhibits sebum production and sebocyte proliferation, and augments sebum excretion in hamsters. J Invest Dermatol. 2007;127(12):2740-8. DOI: 10.1038/sj.jid.5700927. PMID: 17597820.

Docherty JJ, McEwen HA, Sweet TJ, Bailey E, Booth TD. Resveratrol inhibition of Propionibacterium acnes. J Antimicrob Chemother. 2007;59:1182–1184. DOI: 10.1093/jac/dkm099.[PMID: 17449884.

Lim Y-H, Kim I-H, Seo J-J. In vitro activity of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes. J Microbiol Seoul Korea. 2007;45:473–477. PMID: 17978809.

Frequently Asked Questions. National Institutes of Health: Office of Dietary Supplements. Updated February 5, 2021. Available from: https://ods.od.nih.gov/HealthInformation/ODS_Frequently_Asked_Questions.aspx. Accessed April 6, 2021.

Dietary Supplements: What You Need to Know. National Institutes of Health: Office of Dietary Supplements. Updated September 3, 2020. Available from: https://ods.od.nih.gov/factsheets/WYNTK-Consumer/. Accessed April 6, 2021.

Saper RB, Phillips RS, Sehgal A, et al. Lead, mercury, and arsenic in US- and Indian-manufactured Ayurvedic medicines sold via the Internet. JAMA. 2008;300:915–923 DOI: 10.1001/jama.300.8.915. PMID: 18728265; PMCID: PMC2755247.

O’Connor A. New York Attorney General Targets Supplements at Major Retailers. N Y Times. 2015. Available from: https://well.blogs.nytimes.com/2015/02/03/new-york-attorney-general-targets-supplements-at-major-retailers/.

Rothman KJ, Moore LL, Singer MR, Nguyen US, Mannino S, Milunsky A. Teratogenicity of high vitamin A intake. N Engl J Med. 1995;333(21):1369-7133. DOI: 10.1056/NEJM199511233332101. PMID: 7477116.

Zamil D, Burns E, Perez-Sanchez A, Parke M, Katta R. Risk of Birth Defects From Vitamin A “Acne Supplements” Sold Online. Dermatol Pract Concept. 2021;11(3):e2021075. DOI: 10.5826/dpc.1103a75. PMID: 34123566; PMCID: PMC8172008.

Fathizadeh N, Ebrahimi E, Valiani M, Tavakoli N, Yar MH. Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iran J Nurs Midwifery Res. 2010;15:401–405. PMID: 22069417. PMCID: PMC3208934.

Schellenberg R, Zimmermann C, Drewe J, Hoexter G, Zahner C. Dose-dependent efficacy of the Vitex agnus castus extract Ze 440 in patients suffering from premenstrual syndrome. Phytomedicine. 2012;19:1325–31. DOI: 10.1016/j.phymed.2012.08.006. PMID: 23022391.

Leung LH. A Stone that Kills two Birds: How Pantothenic Acid Unveils the Mysteries of Acne Vulgaris and Obesity. Journal of Orthomolecular Medicine. 1997; 12(2). Accessed July 2021. http://orthomolecular.org/library/jom/1997/articles/1997-v12n02-p099.shtml

Sharif A, Akhtar N, Khan MS, et al. Formulation and evaluation on human skin of a water-in-oil emulsion containing Muscat hamburg black grape seed extract. Int J Cosmet Sci. 2015;37:253–258. DOI: 10.1111/ics.12184. PMID: 25402429.

Burns EK, Perez-Sanchez A, Katta R. Risks of Skin, Hair, and Nail Supplements. Dermatol Pract Concept. 2020;10:e2020089. DOI: 10.5826/dpc.1004a89. PMID: 33150030. PMCID: PMC7588165.

Zamil DH, Perez-Sanchez A, Katta R. Acne related to dietary supplements. Dermatol Online J. 2020; 26(8):13030/qt9rp7t2p2. PMID: 32941710.

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Published

2022-02-02

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Original Article

How to Cite

1.
Acne Supplements Sold Online. Dermatol Pract Concept [Internet]. 2022 Feb. 2 [cited 2024 Apr. 23];12(1):e2022029. Available from: https://dpcj.org/index.php/dpc/article/view/1751

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