Extrafacial Lentigo Maligna: A Clinical And Dermoscopic Analysis According to Localization
Keywords:
skin cancer, melanoma, lentigo maligna, dermoscopyAbstract
Introduction: Whether extrafacial lentigo maligna (EFLM) differs clinically and/or dermoscopically according to location has not been analyzed in depth.
Objectives: To evaluate clinical and dermoscopic characteristics regarding different localization in a series of EFLM.
Methods: We conducted a retrospective analysis of clinical and dermoscopic characteristics of 69 histologically proven EFLM retrieved from the database of two private institutions.
Results: Of the 69 EFLM included in the study, 25 (36.2%) were located in posterior trunk (PT), 16 (23.2%) in anterior trunk (AT), 15 (21%) in upper extremities (UE), and 13 (18.8%) in lower extremities (LE). Mean diameter among localization were as follows: 14.3 mm in PT, 11.8 mm in AT, 14 mm in UE, and 10 mm in LE (p 0.44). The most frequent dermoscopic criteria were angulated lines and tan structureless areas (70%), followed by atypical pigment network (60%), both with similar distribution among groups. Angulated lines pattern was the most frequent global pattern, observed in 55% of cases. Tan structureless/granularity pattern and patchy peripheral pigmented islands pattern were seen in 15.6% and 11.6% cases, respectively. No statistically significant differences were observed in the distribution of global dermoscopic pattern in the different localizations.
Conclusions: From the clinical point of view, EFLM did not differ in terms of patient’s age and diameter regarding localization. Upon dermoscopy, we found no significant differences in the overall dermoscopic pattern in the different localizations.
References
Clark WH, Mihm MC. Lentigo maligna and lentigo-maligna melanoma. Am J Pathol. 1969;55(1):39–67. PMID: 5776171. PMCID: PMC2013384.
Bafounta ML, Beauchet A, Aegerter P, Saiag P. Is dermoscopy (epiluminescence microscopy) useful for the diagnosis of melanoma? Results of a meta-analysis using techniques adapted to the evaluation of diagnostic tests. Arch Dermatol. 2001;137:1343-1350. DOI: 10.1001/archderm.137.10.1343. PMID: 11594860.
Kittler H, Pehamberger H, Wolff K, Binder M. Diagnostic accuracy of dermoscopy. Lancet Oncol. 2002;3:159-165. DOI: 10.1016/s1470-2045(02)00679-4. PMID: 11902502.
Jaimes N, Marghoob AA, Rabinovitz H, et al. Clinical and dermoscopic characteristics of melanomas on nonfacial chronically sun-damaged skin. J Am Acad Dermatol. 2015 Jun;72(6):1027-1035. DOI: 10.1016/j.jaad.2015.02.1117. PMID: 25824275.
Keir J. Dermatoscopic features of cutaneous non-facial non-acral lentiginous growth pattern melanomas. Dermatol Pract Concept. 2014;4(1):77-82. DOI: 10.5826/dpc.0401a13. PMID: 24520520. PMCID: PMC3919846.
Lau YN, Affleck AG, Fleming CJ. Dermatoscopic features of extrafacial lentigo maligna. Clin Exp Dermatol. 2013;38(6):612-616. DOI: 10.1111/ced.12063. PMID: 23837933.
Michalik EE, Fitzpatrick TB, Sober AJ. Rapid progression of lentigo maligna to deeply invasive lentigo maligna melanoma. Report of two cases. Arch Dermatol. 1983119(10):831-835. PMID: 6614952.
Kilinc-Karaarslan I, Akalin T, Ozdemir F. Lentigo maligna melanoma with folliculotropism: dermoscopic features during rapid progression. Arch Dermatol. 2009;145(6):725-726. DOI: 10.1001/archdermatol.2009.101. PMID: 19528438.
Stolz W, Schiffner R, Burgdorf WH. Dermatoscopy for facial pigmented skin lesions. Clin Dermatol. 2002;20(3):276-278. DOI: 10.1016/s0738-081x(02)00221-3. PMID: 12074867.
Published
Issue
Section
License
Copyright (c) 2022 Gabriel Salerni, Horacio Cabo, Emilia Cohen-Sabban
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Dermatology Practical & Conceptual applies a Creative Commons Attribution License (CCAL) to all works we publish (http://creativecommons.org/licenses/by-nc/4.0/). Authors retain the copyright for their published work.