The Role of EREG, PTPN1, and SERPINB7 Genes in the Pathogenesis of Psoriasis: May SERPINB7 Be Protective and a Marker of Severity for Psoriasis?

The Role of EREG, PTPN1, and SERPINB7 Genes in the Pathogenesis of Psoriasis: May SERPINB7 Be Protective and a Marker of Severity for Psoriasis?

Authors

  • Havva Hilal Ayvaz Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta,Turkey
  • Kuyaş Hekimler Öztürk Department of Medical Genetics, Faculty of Medicine, Suleyman Demirel University, Isparta/Turkey
  • Mehmet Ali Seyirci Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
  • Emrah Atay Public health expertise, Eskişehir Directorate of Health, Eskişehir/Turkey
  • Selma Korkmaz Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta/Turkey
  • İjlal Erturan Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta/Turkey
  • Mehmet Yıldırım Department of Dermatology, Faculty of Medicine, Suleyman Demirel University, Isparta/Turkey

Keywords:

psoriasis, epiregulin, tyrosine-protein phosphatase non-receptor type 1, serine proteinase inhibitors

Abstract

Introduction: Psoriasis is a chronic inflammatory dermatological disease with complex pathogenesis in which many immune system cells, including keratinocytes, play a role. Many genes regulate the proliferation of keratinocytes and other immune cells that have essential roles in the pathogenesis of psoriasis.The expressions of EREG, PTPN1, and SERPINB7 genes were shown as upregulated in psoriatic skins in a few studies previously.

Objectives: We aimed to evaluate the expressions of these genes in psoriatic lesional skin and com-pared them with non-lesional adjacent skin of the same patients and normal skin of healthy controls.

Results: Our results revealed that the expressions of EREG and PTPN1 genes were upregulated,whereas the SERPINB7 gene expression was down regulated in the psoriatic skin of the patients than normal skin of controls. Moreover, the expression level of the SERPINB7 gene was also negatively correlated with the severity of the disease among patients.

Conclusions: According to our results, overexpression of EREG and PTPN1 genes, and decreased expression of SERPINB7 gene may lead to the development of psoriasis.

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Published

2023-04-29

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Original Article

How to Cite

1.
The Role of EREG, PTPN1, and SERPINB7 Genes in the Pathogenesis of Psoriasis: May SERPINB7 Be Protective and a Marker of Severity for Psoriasis? . Dermatol Pract Concept [Internet]. 2023 Apr. 29 [cited 2024 May 19];13(2):e2023085. Available from: https://dpcj.org/index.php/dpc/article/view/2650

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