A Non-interventional Study on Vismodegib for Basal Cell Carcinoma With A Treat-To-Target Regimen In Swedish Patients

A Non-interventional Study on Vismodegib for Basal Cell Carcinoma With A Treat-To-Target Regimen In Swedish Patients

Authors

  • Niels Bendsöe Skåne University Hospital, Department of Dermatology and Venereology, Lund, Sweden
  • John Paoli Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  • Karin Söderkvist Department of Oncology, Norrlands University Hospital, Umeå, Sweden
  • Bertil Persson Skåne University Hospital, Department of Dermatology and Venereology, Lund, Sweden
  • Christina Halldin Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  • Linda Ihrlund Roche AB, Sweden
  • Maria Wolodarski Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden

Keywords:

Non-interventional, prospective, effectiveness, safety, cohort-study

Abstract

Introduction: Real-life data on vismodegib in advanced basal cell carcinoma (aBCC) are limited. Optimal treatment duration is left to the discretion of the physician.

Objectives: To assess the effectiveness, safety and treatment pattern for vismodegib in aBCC in clinical practice.

Methods: In this multicenter, non-interventional, prospective study, 49 Swedish patients planned for vismodegib treatment were included. The treatment pattern observed was treatment until remission, allowing unlimited discontinuations/pauses.

Results: The majority of patients (93.8%), discontinued at least once during the study. Compared to earlier studies there was a decrease of more than 2 months with actual drug intake, reducing the patients burden and costs, at the same time as a high number of responses were seen (87.8%). Median progression-free-survival was 16.7 months, and 90% of the patients were alive at 13.3 months. Ten patients were re-challenged with vismodegib at recurrence or progression, resulting in five partial remissions and three complete remissions. 

Conclusions: Clinical response rates with vismodegib for aBCC were similar to those of similar trials despite a shorter and more intermittent treatment duration. The majority of re-challenges lead to partial or complete remissions.

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Published

2023-04-29

How to Cite

1.
A Non-interventional Study on Vismodegib for Basal Cell Carcinoma With A Treat-To-Target Regimen In Swedish Patients. Dermatol Pract Concept [Internet]. 2023 Apr. 29 [cited 2024 Dec. 6];13(2):e2023211. Available from: https://dpcj.org/index.php/dpc/article/view/3032

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