A 50-year-old woman presented an erythematous desquamative plantar eruption occurred 6 months prior to the visit ( Figure 1A ). Several treatments with topical potent corticosteroids and antimycotics were given in the clinical suspect of dyshidrotic eczema, without improvement.
Histological examination showed parakeratosis, hypogranulosis and psoriasiform epidermal hyperplasia and neutrophils in the stratum corneum, forming Munro micro-abscesses, confirming the diagnosis of psoriasis ( Figure 1C ).
A further investigation of medical history revealed that the patient was affected by Crohn disease, and successfully treated with adalimumab in the last 5 years. A diagnosis of paradoxical psoriasis was proposed, and in agreement with the gastroenterologist, biological therapy was switched to ustekinumab. In addition, calcipotriol/betamethasone dipropionate ointment was started. At 3 months of followup, the plantar lesions were completely resolved, without Crohn’s disease relapses.
Paradoxical psoriasis is a well-documented manifestation in patients with inflammatory bowel disease treated with anti-TNF-α agents [ 2 ] . The pathological mechanism of the onset of psoriasis due to anti-TNF-α seems related to the migration of T cells to the skin induced by IFN-α produced by plasmacytoid dendritic cells.
Dermoscopy in palmoplantar localization could be crucial for a differential diagnosis: in chronic dyshidrotic eczema yellow scales and brownish dots/globules are usually detected ( Figure 1D ) corresponding to tiny spongiotic vesicles; while psoriasis is characterized by white scales and regular distributed red dots.
In these cases, the withdrawal from anti-TNF-α usually induces a complete remission of the skin lesions, thus confirming a reversible and drug-related side effect.
In our case, given the personal history of Crohn disease, a switch to a biological drug of another class was successfully undertaken.
Patient Consent: Informed consent for the use of information and images has been obtained from the patient.
- Dermoscopic clues of palmoplantar hyperkeratotic eczema and palmoplantar psoriasis: A prospective, comparative study of 90 patients Çetinarslan T, Türel Ermertcan A, Temiz P. J Dermatol.2020;47(10):1157-1165. CrossRef PubMed
- Paradoxical psoriasis in a large cohort of patients with inflammatory bowel disease receiving treatment with anti-TNF alpha: 5-year follow-up study Pugliese D, Guidi L, Ferraro PM, et al. Aliment Pharmacol Ther.2015;42(7):880-888. CrossRef PubMed