The Role of Sentinel Node Biopsy in the Era of Adjuvant Therapy for Melanoma

The Role of Sentinel Node Biopsy in the Era of Adjuvant Therapy for Melanoma

Authors

  • Gabriella Brancaccio Dermatology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy
  • Giulia Briatico Dermatology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy
  • Camila Scharf Dermatology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy
  • Giuseppe Colella Multidisciplinary Department of Medical, Surgical and Dental Specialties, Oral and Maxillofacial Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy
  • Giovanni Docimo Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy
  • Ludovico Docimo Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy
  • Mario Faenza Multidisciplinary Department of Medical, Surgical and Dental Sciences, Plastic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy
  • Francesco Iovino Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy
  • Salvatore Tolone Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy
  • Pasquale Verolino Unit of Plastic Surgery, Multidisciplinary Department of Medical Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli"
  • Stefania Napolitano Department of Precision Medicine, Medical Oncology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy
  • Teresa Troiani Department of Precision Medicine, Medical Oncology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy
  • Andrea Ronchi Division of Pathology, Department of Mental Health and Preventive Medicine, “Luigi Vanvitelli” University of Campania, Naples, Italy
  • Renato Franco Division of Pathology, Department of Mental Health and Preventive Medicine, “Luigi Vanvitelli” University of Campania, Naples, Italy
  • Giuseppe Argenziano Dermatology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy https://orcid.org/0000-0003-1413-8214

Keywords:

melanoma, adjuvant therapy, sentinel node biopsy

Abstract

Sentinel lymph node biopsy (SLNB) is a surgical procedure aimed to detect nodal metastases in patients with clinically occult disease. Since the advent of new systemic therapies, its role in melanoma has been extensively debated over the last years. In this article, three possible scenarios are discussed, considering the SLNB impact on the management of melanoma patients. First, pT1b and pT2a patients with negative SLNB (stages IA and IB) and those with positive SLNB (stage IIIA) would all not benefit from adjuvant treatment. Therefore, SLNB might be avoided in these categories of patients. Second, in IIB and IIC, melanoma patients are already candidates for adjuvant treatment; therefore, SLNB in patients with T3b, T4a, or T4b melanoma would not change treatment decisions. On the other end of the spectrum, patients with pT2b and pT3a melanomas (clinical stage IIA) represent the only two groups whose management would be significantly affected by the SLNB status, being adjuvant therapy only indicated for SLN-positive patients. Further studies are needed to investigate which melanoma patient deserves SLNB.

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Published

2024-01-31

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Review

How to Cite

1.
The Role of Sentinel Node Biopsy in the Era of Adjuvant Therapy for Melanoma. Dermatol Pract Concept [Internet]. 2024 Jan. 31 [cited 2024 Apr. 23];14(1):e2024038. Available from: https://dpcj.org/index.php/dpc/article/view/3378

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