Cutaneous Squamous Cell Carcinoma: Clinico-Dermoscopic and Histological Correlation: About 72 Cases

Cutaneous Squamous Cell Carcinoma: Clinico-Dermoscopic and Histological Correlation: About 72 Cases

Authors

  • Sara El-Ammari Department of Dermatology, University Hospital Hassan II, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco
  • Sara Elloudi Department of Dermatology, University Hospital Hassan II, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco
  • Hanane Baybay Department of Dermatology, University Hospital Hassan II, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco
  • Meryem Soughi Department of Dermatology, University Hospital Hassan II, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco
  • Zakia Douhi Department of Dermatology, University Hospital Hassan II, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco
  • Fatima Zahra Mernissi Department of Dermatology, University Hospital Hassan II, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco
  • Mohammed Omari Laboratory of Epidemiology, Clinical Research and Community Health- Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco
  • Samira El fakir Laboratory of Epidemiology, Clinical Research and Community Health- Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco
  • Layla Tahiri Anatomical pathology laboratory, University Hospital Hassan II, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco

Keywords:

clinical form, histopathological grade of differentiation, dermoscopy, Cutaneous squamous cell carcinoma

Abstract

Introduction: Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer. It represents 20% of malignant skin tumors. Dermoscopy is a very useful tool for its diagnosis, which is confirmed by anatomo-pathological study.

Objective: to describe the different dermoscopic structures of cSCC and to investigate their association with clinical form and histopathological grade of differentiation.

Methods: Retro-prospective epidemiological study, collecting patients with squamous cell carcinoma over a period of 5 years. We divided our study population into two groups according to the degree of histological differentiation (well-differentiated and non-well-differentiated) and according to the clinical form (nodulo-ulcerative and nodular) and compared different dermoscopic parameters between these two groups.

Results: Of 72 invasive cSCC, 81.9% were well-differentiated and 18.1% were non-well- differentiated, the clinical form of cSCC was nodulo-ulcerative in 83.3% and nodular in 16.7%. The well-differentiated tumors showed dotted, glomerular and hairpin vessels and the predominance of a white pattern made of centrally distributed keratin as well as white circles, whitish perivascular halo, the distribution of these white structures was radial in nodulo-ulcerarive lesions in contrast to nodular lesions where their distribution as well as that of the keratin was rather diffuse. Non-well-differentiated tumors showed a combined white-red pattern with the predominance of arborizing vessels.

Conclusion:Our results show that dermoscopy can be considered a reliable tool to distinguish between well- and poorly differentiated cSCC, the transition from one to the other is represented by an increase in the amount of mostly arborizing vessels and the decrease in white structures.

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Published

2024-01-31

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Cutaneous Squamous Cell Carcinoma: Clinico-Dermoscopic and Histological Correlation: About 72 Cases. Dermatol Pract Concept [Internet]. 2024 Jan. 31 [cited 2024 Oct. 9];14(1):e2024042. Available from: https://dpcj.org/index.php/dpc/article/view/3460

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