Research Letter

Unilateral Verrucous Psoriasis Successfully Treated With Adalimumab

Author Affiliation(s)


Verrucous psoriasis (VP) is a rare variant of psoriasis that typically arises in patients with established psoriasis but can occur de novo [ 1 ] . There is a higher prevalence in men [ 2 ] . The disease usually appears in areas of friction, and is associated with obesity, diabetes mellitus, and peripheral circulatory failure [ 3 ] . We report a case of unilateral verrucous psoriasis with a good response to treatment with adalimumab.

Case Presentation

A 31-year-old female patient reported pruritic scaly erythematous lesions over the body for 5 years. Previous betamethasone with salicylic acid cream without improvement of the lesions was used. She had a personal history of obesity grade II and was asthmatic using formoterol fumarate dihydrate plus budesonide. Dermatological examination found scaly erythematous plaques with thick, verrucous-like crusts, well adherent in the lower left quadrant of the abdomen, left breast (medial upper quadrant) and left axilla. The lesions followed Blaschko lines and did not extend beyond the mid-line ( Figure 1 ).

A skin biopsy showed regular psoriasiform acanthosis of the epidermis, widening of the bases of the interpapillary ridges, thinning of the suprapapillary portion, laminar hyperparakeratosis containing Munro microabscesses, Kogoj spongiform pustule in the epidermis and dilatation, capillary tortuosity in the papillary dermis ( Figure 2 ).

Clinical and histopathological findings led to the diagnosis of unilateral verrucous psoriasis. Treatment with clobetasol, methotrexate oral and UVB-NB phototherapy was started with partial response. Adalimumab (40 mg every two weeks) was then opted out and showed efficacy of 90% (psoriasis area severity index [PASI] 90) after 12 weeks ( Figure 3 ).


VP is characterized by symmetric hypertrophic verrucous plaques that may have an erythematous base and involve the legs, arms, trunk, and dorsal aspect of the hands; malodor is frequent [ 4 ] .

It has been hypothesized that marked hyperkeratosis is induced by repeat trauma to the extremities in patients with established psoriasis or by anoxia from conditions that predispose to poor circulation, such as diabetes mellitus and pulmonary disease [ 3 ] .

The diagnosis of VP can be challenging because of its similarity to other entities, including verruca vulgaris; epidermal nevus; contact dermatitis, eczema, fungal infection and squamous cell carcinoma [ 4 ,5] . Histopathologically, overlapping features of verruca vulgaris and psoriasis have been described [ 2 , 4 ] .

Regarding treatment, this condition is sometimes refractory. Use of topical therapies such as corticosteroids and keratolytics has minimal response in monotherapy. The greatest successes reported so far have been with systemic therapy such as methotrexate and acitretin, used alone or in combination [ 4 ] . As for immuno-biologicals, the few reported cases showed only a partial response.

However, the unilateral variant of VP is even more uncommon, with only one case reported in the literature so far. In this case, only topical treatment was chosen, as the patient refused systemic therapy.

We report the first case of unilateral verrucous psoriasis that, after refractoriness to treatment with topical corticosteroids, phototherapy and oral methotrexate, showed an excellent response to the immuno-biological Adalimumab, reaching PASI 90 after 12 weeks of treatment. Therefore, we aim to contribute to the recognition of this entity and promote more assertive therapeutic alternatives.


  1. Unilateral Verrucous Psoriasis Sanyal RD, Vyas NS, Sapadin AN, Phelps RG. Cutis.2021;107(2):97-98. CrossRef PubMed
  2. Psoriasis with verrucous appearance: a case report Rejeb SB, Dhaoui A, Ghachem DB, Souissi A, Bellil K. Our Dermatology Online.2017;8(1):63-65. CrossRef
  3. Verrucous Psoriasis: A Distinctive Clinicopathologic Variant of Psoriasis Khalil FK, Keehn CA, Saeed S, Morgan MB. Am J Dermatopathol.2005;27(3):204-207. CrossRef PubMed
  4. Verrucous psoriasis treated with methotrexate and acitretin combination therapy Shivers L, Montanez-Wiscovich ME. Cutis.2019;104(6):E10-E12.

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