Frequency and Correlation of Peripheral and Tissue Eosinophilia With Clinical Manifestations in Patients With Bullous Pemphigoid

Bahareh Abtahi-Naeini; Farhad  Zare-Mehrjerdi; Zabihollah   Shahmoradi; Fereshte Rastegarnasab; Mojtaba   Akbari; Azadeh   Zolfaghari; Asiyeh  Heidari; Fateme  Mohaghegh

doi:10.5826/dpc.1403a169

Frequency and Correlation of Peripheral and Tissue Eosinophilia With Clinical Manifestations in Patients With Bullous Pemphigoid

Authors

Bahareh Abtahi-Naeini Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Farhad Zare-Mehrjerdi Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
Zabihollah Shahmoradi Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Fereshte Rastegarnasab Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
Mojtaba Akbari Department of Epidemiology, School of Health, Isfahan University of Medical Sciences, Iran
Azadeh Zolfaghari Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Asiyeh Heidari Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Fateme Mohaghegh Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Keywords:

bullous pemphigoid, eosinophilia, eosinophils, BPDAI

Abstract

Introduction: Bullous pemphigoid (BP) is an autoimmune disease involving the sub-epidermal layer. Eosinophilia may play a role in the pathogenesis of BP.

Objectives: We aimed to investigate the correlation between dermal or peripheral eosinophilia with clinical presentations in patients with BP.

Methods: This cross-sectional study was conducted on 108 BP patients from January 2010 to September 2019. Clinical data were recovered. Skin biopsies were re-evaluated, and the Bullous Pemphigoid Disease Area Index (BPDAI) severity score was calculated. Finally, the relationship between clinical features of BP and dermal or peripheral eosinophilia was analyzed.

Results: A total number of 108 patients were included in this study. Thirty-five were excluded due to our exclusion criteria. Finally, data from 73 patients were analyzed. 57.5% of the population was female. There was a significant direct correlation (r= 0.33) between BPDAI severity score and tissue eosinophilia (p= 0.03). No significant relationship was found between BPDAI severity score and peripheral eosinophilia (P= 0.52). There were significant positive correlations between tissue eosinophilia with absolute serum eosinophil count (P= 0.002; r= 0.49) and percentage (P< 0.0001; r= 0.89).

Conclusion: This study revealed significant relationships between tissue eosinophilia and BP severity. These findings could be useful in clinical practice. The possible role of eosinophils in BP clinical features should be considered as a promising help for better diagnosis and treatment.

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