Impact of Xerosis in Patients With Cancer Receiving Epidermal Growth Factor Receptor or Mitogen-Activated Protein Kinase Inhibitors: ATIXI, A Non-Interventional, Prospective, Pilot Study

Impact of Xerosis in Patients With Cancer Receiving Epidermal Growth Factor Receptor or Mitogen-Activated Protein Kinase Inhibitors: ATIXI, A Non-Interventional, Prospective, Pilot Study

Authors

  • Pietro Quaglino Dermatologic Clinic, Department of Medical Sciences, University of Turin, Turin, Italy
  • Giuseppe Argenziano Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli Naples, Naples, Italy
  • Emi Dika Oncologic Dermatology Unit , IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy Department of Medical and Surgical Sciences , Alma Mater Studiorum University of Bologna, Italy
  • Michela Starace Department of Medical and Surgical Sciences , Alma Mater Studiorum University of Bologna, Italy Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
  • Simone Amabile Dermatologic Clinic, Department of Medical Sciences, University of Turin, Turin, Italy
  • Paolo Fava Dermatologic Clinic, Department of Medical Sciences, University of Turin, Turin, Italy
  • Elvira Moscarella Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli Naples, Naples, Italy
  • Bianca Maria Piraccini Department of Medical and Surgical Sciences , Alma Mater Studiorum University of Bologna, Italy Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
  • Alain Delarue Pierre Fabre, Lavaur, France
  • Olivia Dialla Pierre Fabre, Boulogne-Billancourt, France
  • Fabienne Zumaglini Pierre Fabre, Lavaur, France
  • Giampiero Girolomoni Department of Medicine, Section of Dermatology, University of Verona, Verona, Italy

Keywords:

adverse effects, anti-cancer treatments, cutaneous toxicity, EGFR inhibitors, MEK inhibitors, xerosis

References

Lacouture M, Sibaud V. Toxic side effects of targeted therapies and immunotherapies affecting the skin, oral mucosa, hair, and nails. Am J Clin Dermatol. 2018;19(Suppl 1):31–9. DOI: 10.1007/s40257-018-0384-3.

Robert C, Soria JC, Spatz A, et al. Cutaneous side-effects of kinase inhibitors and blocking antibodies. Lancet Oncol. 2005;6(7):491-500. DOI:10.1016/S1470-2045(05)70243-6.

Valentine J, Belum VR, Duran J, et al. Incidence and risk of xerosis with targeted anticancer therapies. J Am Acad Dermatol. 2015;72(4):656-667. DOI:10.1016/j.jaad.2014.12.010.

Lee J, Lim J, Park JS, et al. The Impact of Skin Problems on the Quality of Life in Patients Treated with Anticancer Agents: A Cross-Sectional Study. Cancer Res Treat. 2018;50(4):1186-1193. DOI:10.4143/crt.2017.435.

Lacouture ME. Mechanisms of cutaneous toxicities to EGFR inhibitors. Nat Rev Cancer. 2006;6(10):803-812. DOI:10.1038/nrc1970.

Pastore S, Lulli D, Girolomoni G. Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors. Arch Toxicol. 2014;88(6):1189-1203. DOI:10.1007/s00204-014-1244-4.

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Published

2024-10-30

How to Cite

1.
Impact of Xerosis in Patients With Cancer Receiving Epidermal Growth Factor Receptor or Mitogen-Activated Protein Kinase Inhibitors: ATIXI, A Non-Interventional, Prospective, Pilot Study. Dermatol Pract Concept [Internet]. 2024 Oct. 30 [cited 2024 Dec. 3];14(4):e2024259. Available from: https://dpcj.org/index.php/dpc/article/view/4390

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