Melanocytic Skin Tumors: Does the Molecular Progression Model Fit With the Routine Clinicopathological Practice?

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The correlation between molecular and histopathological features of melanocytic tumors is still largely incomplete. From a practical point of view, however, only a very limited number of cases seen in clinical practice run the entire spectrum of molecular and biological progression of melanomagenesis; thus, the molecular progression model has a very limited clinical impact. Rather than intermediate stages in an unlikely path toward melanoma, melanocytomas are probably best regarded as morphobiologically peculiar melanocytic tumors, namely, strongly lymphotropic (low-grade) melanocytic malignancies; their clinical management should be thus discussed case by case in a multidisciplinary setting by integrating the histopathological findings with the clinical data.


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