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Meyerson Phenomenon Over Nuchal Nevus Simplex

Author Affiliation(s)

Case Presentation

Two infants aged 11 and 5 months consulted for eczematous plaques on the nape. Their parents reported that the lesions had developed over previous erythematous stains. Both cases corresponded to eczematous changes over nevus simplex, known as Meyerson phenomenon (Figure 1).

Figure 1 .

Two cases of Meyerson phenomenon over nuchal nevus simplex.

Teaching Point

Meyerson phenomenon is defined as a spontaneous eczematous reaction within an overlying skin lesion. This phenomenon was first reported in melanocytic lesions [ 1 ] ; however, it has also been related to seborrheic keratosis, dermatofibroma, molluscum contagiosum, and many other lesions. Although many hypotheses have been proposed, its origin is still unknown, and its relationship with atopic dermatitis remains controversial. Even though Meyerson phenomenon over capillary malformations is not frequent, it has been associated with nevus simplex [ 2 , 3 ] , port-wine stains [ 4 ] , and trunk and limb capillary malformations [ 5 ] . Exceptionally, it has been reported after laser treatment [ 4 ] . Although its diagnosis is clinical, in doubtful cases we may perform histopathological study. Histopathological findings include characteristic features of eczema such as spongiosis, acanthosis, parakeratosis, and superficial dermal lymphocytic infiltrate overlying capillary ectasias [ 1 , 5 ] . Prognosis is good, and topical corticosteroids are usually successfully used to treat the eczema. Nevertheless, some lesions may recur after treatment discontinuation, and pulsed dye laser therapy sometimes may be needed [ 2 , 5 ] .


  1. Meyerson phenomenon Loh J, Kenny P. J Cutan Med Surg.2010;14(1):30-32. CrossRef PubMed
  2. Inflammatory nuchal-occipital port-wine stains Tay YK, Morelli J, Weston WL. J Am Acad Dermatol.1996;35(5 Pt 2):811-813. CrossRef PubMed
  3. Vascular stains: proposal for a clinical classification to improve diagnosis and management Rozas-Muñoz E, Frieden IJ, Roé E, Puig L, Baselga E. Pediatr Dermatol.2016;33(6):570-584. CrossRef PubMed
  4. Eczema within port wine stain: spontaneous and laser-induced Meyerson phenomenon Pavlovic MD, Adamic M. Acta Dermatovenerol Alp Pannonica Adriat.2014;23(4):81-83. CrossRef PubMed
  5. Eczema within a capillary malformation: a case of Meyerson phenomenon Kim SJ, Kim YC. Ann Dermatol.2016;28(6):781-782. CrossRef PubMed

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