Dermoscopic Features as Predictors of BRAF Mutational Status and Sentinel Lymph Node Positivity in Primary Cutaneous Melanoma
Keywords:
melanoma, BRAF, sentinel lymph node, dermoscopyAbstract
Dermoscopy is a diagnostic tool widely used in clinical practice for the detection of skin tumors, especially early stages of melanoma. Recent studies have shown that different dermoscopic features are associated with important prognostic parameters of melanoma, such as BRAF mutational status and sentinel lymph node status. More than half of all melanomas harbor a mutation in the BRAF oncogene. The current management of advanced-stage melanomas is greatly determined by the presence or absence of a mutation in this gene, as targeted therapy with BRAF kinase inhibitors is one of the first therapeutic choices for these patients. Sentinel lymph node status is one of the most significant predictors of a melanoma patient’s survival. Recent studies have shown that different dermoscopic patterns are also associated with sentinel lymph node status. This short article reviews studies that investigated correlations between dermoscopic features, BRAF mutation status and sentinel lymph node status.
References
National Cancer Institute. (2020, April 15). Surveillance, Epidemiology, and End Results (SEER). Program Cancer Statistics Review, 1975-2017. Accessed August 20, 2020. https://seer.cancer.gov/csr/1975-2017
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. DOI: 10.3322/caac.21492. PMID: 30207593.
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949-54. DOI: 10.1038/nature00766.
Lee JH, Choi JW, Kim YS. Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis. Br J Dermatol. 2011;164(4):776-784. DOI: 10.1111/j.1365-2133.2010.10185.x. PMID: 21166657.
Kim SY, Kim SN, Hahn HJ, Lee YW, Choe YB, Ahn KJ. Metaanalysis of BRAF mutations and clinicopathologic characteristics in primary melanoma. J Am Acad Dermatol. 2015;72(6):1036-1046.e2. DOI:10.1016/j.jaad.2015.02.1113. PMID: 25819940.
Liu W, Kelly JW, Trivett M, et al. Distinct clinical and pathological features are associated with the BRAFT1799A(V600E) mutation in primary melanoma. J Invest Dermatol. 2007;127(4):900-905. DOI:10.1038/sj.jid.5700632. PMID: 17159915.
Thomas NE, Edmiston SN, Alexander A, et al. Association between NRAS and BRAF mutational status and melanoma-specific survival among patients with higher-risk primary melanoma.JAMA Oncol. 2015;1(3):359-368. DOI: 10.1001/jamaoncol. 2015.0493. PMID: 26146664.
García-Casado Z, Traves V, Bañuls J, et al. BRAF, NRAS and MC1R status in a prospective series of primary cutaneous melanoma. Br J Dermatol. 2015;172(4) 1128-1131. DOI: 10.1111/bjd.13521. PMID: 25385688.4 Review | Dermatol Pract Concept. 2021;11(2):e2021040
Bauer J, Büttner P, Murali R, et al. BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site. Pigment Cell Melanoma Res. 2011;24(2):345-351. DOI: 10.1111/j.1755-148X.2011.00837.x. PMID:21324100.
Coit DG, Thompson JA, Algazi A, et al. NCCN Guidelines insights: Melanoma, version 3.2016. J Natl Compr Canc Netw. 2016;14(8):945-958. DOI: 10.6004/jnccn.2016.0101. PMID:27496110.
Gandolfi G, Longo C, Moscarella E, et al. The extent of whole-genome copy number alterations predicts aggressive features in primary melanomas. Pigment Cell Melanoma Res. 2016;29(2):163-175. DOI:10.1111/pcmr.12436. PMID: 26575206.
Gershenwald JE, Colyer RA. Melanoma Staging: American Joint Committee on Cancer (AJCC) 8th Edition and Beyond. Ann Surg Oncol. 2018;25(8):2105-2110. DOI: 10.1245/s10434-018-6513-7.
Pozzobon FC, Puig-Butillé JA, González-Alvarez T, et al. Dermoscopiccriteria associated with BRAF and NRAS mutation status in primary cutaneous melanoma. Br J Dermatol. 2014;171(4):754-759. DOI:10.1111/bjd.13069. PMID: 24749938.
Phan A, Dalle S, Touzet S, Ronger-Savlé S, Balme B, Thomas L. Dermoscopic features of acral lentiginous melanoma in a large series of 110 cases in a white population. Br J Dermatol. 2010;162(4):765-771. DOI:10.1111/j.1365-2133.2009.09594.x.PMID: 19922528.
Pralong P, Bathelier E, Dalle S, Poulalhon N, Debarbieux S, Thomas L. Dermoscopy of lentigo maligna melanoma: report of 125 cases. Br J Dermatol. 2012;167(2):280-287. DOI: 10.1111/j.1365-2133.2012.10932.x. PMID: 22404578.
Bombonato C, Ribero S, Pozzobon FC, et al. Association between dermoscopic and reflectance confocal microscopy features of cutaneous melanoma with BRAF mutational status. J Eur Acad Dermatol Venereol. 2017;31(4):643-649. DOI: 10.1111/jdv.14028. PMID: 27790766.
Fargnoli MC, Sera F, Suppa M, et al. Dermoscopic features of cutaneous melanoma are associated with clinical characteristics of patients and tumours and with MC1R genotype. J Eur Acad Dermatol Venereol. 2014;28(12):1768-1775. DOI: 10.1111/jdv.12411. PMID: 24588892.
Armengot-Carbó M, Nagore E, García-Casado Z, Botella-Estrada R. The association between dermoscopic features and BRAF mutational status in cutaneous melanoma: Significance of the blue-white veil. J Am Acad Dermatol. 2018;78(5):920-926.e4. DOI: 10.1016/j.jaad.2017.12.064, PMID: 29307636.
Malvehy J, Puig S. Principles of Dermoscopy. Barcelona: Cege Editors, 2002.
Argenziano G, Soyer HP, Chimenti S, et al Dermoscopy of pigmented skin lesions: results of a consensus meeting via the internet.J Am Acad Dermatol. 2003;48(5):679-693. DOI: 10.1067/mjd.2003.281. PMID:12734496.
Neila J, Soyer HP. Key points in dermoscopy for diagnosis of melanomas, including difficult to diagnose melanomas, on the trunk and extremities. J Dermatol. 2011;38(1):3-9. DOI:10.1111/j.1346-8138.2010.01131.x. PMID: 21175749.
Viros A, Fridlyand J, Bauer J, et al. Improving melanoma classification by integrating genetic and morphologic features. PLoS Med. 2008;5(6):e120. DOI: 10.1371/journal.pmed.0050120. PMID: 18532874.
Broekaert SMC, Roy R, Okamoto I, et al. Genetic and morphologic features for melanoma classification. Pigment Cell Melanoma Res. 2010;23(6):763-770. DOI: 10.1111/j.1755-148X.2010.00778.x. PMID: 20874733.
Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catrical C, Argenziano G. How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part I. Melanocytic skin tumors. J Am Acad Dermatol. 2010. p. 361–74. DOI: 10.1016/j.jaad.2009.11.698. PMID: 20708469.
Deinlein T, Arzberger E, Zalaudek I, et al. Dermoscopic characteristics of melanoma according to the criteria “ulceration” and, “mitotic rate” of the AJCC 2009 staging system for melanoma. PLoS ONE. 2017;12(4):e0174871. DOI: 10.1371/journal.pone.0174871. PMID: 28399177.
Gouillon L, Perier-Muzet M, Amini-Adle M, et al. Dermoscopic features in BRAF and NRAS primary cutaneous melanoma: association with peppering and blue-white veil. J Eur Acad Dermatol Venereol. 2020;34(2):357-e59 DOI: 10.1111/jdv.15906. PMID: 31442328.
Zalaudek I, Argenziano G, Ferrara G, et al. Clinically equivocal melanocytic skin lesions with features of regression: a dermoscopic- pathological study. Br J Dermatol. 2004;150(1):64-71. DOI:10.1111/j.1365-2133.2004.05657.x. PMID: 14746618.
Gonzalez A. Sentinel lymph node biopsy: past and present implications for the management of cutaneous melanoma with nodal metastasis. Am J Clin Dermatol. 2018;19(Suppl 1):24-30 DOI: 10.1007/s40257-018-0379-0. PMID: 30374897.
Morton DL, Thompson JF, Cochran AJ, et al. Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med. 2014;370(7):599-609. DOI: 10.1056/NEJMoa1310460. PMID: 24521106.
Thomson DR, Rughani MG, Kuo R, Cassell OCS. Sentinel node biopsy status is strongly predictive of survival in cutaneous melanoma: Extended follow-up of Oxford patients from 1998 to 2014. J Plast Reconstr Aesthet Surg. 2017;70(10):1397-1403. DOI: 10.1016/j.bjps.2017.05.025. PMID: 28625757.
Tejera-Vaquerizo A, Ribero S, Puig S, et al. Survival analysis and sentinel lymph node status in thin cutaneous melanoma: a multicenter observational study. Cancer Med. 2019;8(9):4235-4244. DOI: 10.1002/cam4.2358. PMID: 31215168.
González-Álvarez T, Carrera C, Bennassar A, et al. Dermoscopy structures as predictors of sentinel lymph node positivity in cutaneous melanoma. Br J Dermatol. 2015;172(5):1269-1277. DOI: 10.1111/bjd.13552. PMID:25418318.
Pagnanelli G, Bono R, Pizzichetta MA, et al. Clinical and dermoscopic criteria related to melanoma sentinel lymph node positivity. Anticancer Res. 2007;27(4C):2939-2944. PMID: 17695474.
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