Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare
Citation: Koku Aksu AE, İlhan Erdil D, Manav Baş V, Büşra Türk C, Leblebici C, Tellal ES. Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare. Dermatol Pract Concept. 2023;13(1):e2023113. DOI: https://doi.org/10.5826/dpc.1301a113
Accepted: January 4, 2023; Published: January 2023
Copyright: ©2023 Koku Aksu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Competing interests: None.
Authorship: All authors have contributed significantly to this publication.
Corresponding author: Ayşe Esra Koku Aksu, Health Sciences University, Istanbul Training and Research Hospital, Dermatology Clinic, Istanbul, Turkey. Email: firstname.lastname@example.org
Introduction: Granuloma annulare (GA) is a non-infectious granulomatous disease that can affect children and adults. Although many studies have been conducted adult GA patients, the literature on pediatric GA cases is limited.
Objectives: Therefore, this study aimed to examine the demographic, clinical, and pathological features of pediatric GA cases.
Methods: This study was performed retrospectively in a single-center tertiary dermatology hospital. Demographic characteristics and clinical and histopathological features were recorded.
Results: Forty-one participants were included in this study, of which 66% were female. The mean age was 3.8 ± 2.6 years, and the mean lesion duration was 7.5 ± 10.3 months. The involvement of 78% of the patients was localized, and the remaining 22% was generalized. Asthma (30%) was the most common comorbid disease. Histopathological examination was performed on twenty-one patients, and the infiltrate pattern was interstitial in 71% of the cases and palisadic in 29%. Generalized distribution, trunk involvement, and concomitant disease tended to be higher in patients with an interstitial pattern than in those with a palisadic pattern.
Conclusions: Atopy and asthma should be questioned in pediatric GA cases. There are differences between involvement, distribution, concomitant disease, and histopathological patterns, which may indicate differences in pathogenesis.
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