Bimekizumab for the Treatment of Plaque Psoriasis With Involvement of Genitalia: A 16-Week Multicenter Real-World Experience—IL PSO (Italian Landscape Psoriasis)

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Bimekizumab for the Treatment of Plaque Psoriasis With Involvement of Genitalia: A 16-Week Multicenter Real-World Experience—IL PSO (Italian Landscape Psoriasis)

Authors

  • Diego Orsini Clinical Dermatology Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy
  • Piergiorgio Malagoli Department of Dermatology, Dermatology Unit Azienda Ospedaliera San Donato Milanese, Milan, Italy.
  • Anna Balato Dermatology Unit, University of Campania L. Vanvitelli, Naples, Italy
  • Luca Bianchi Dermatology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
  • Pina Brianti Unit of Dermatology and Cosmetology, IRCCS San Raffaele Scientific Institute, Milan, Italy
  • Dario Buononato Dermatology Unit, University of Campania L. Vanvitelli, Naples, Italy
  • Martina Burlando Section of Dermatology, Department of Health Sciences (DISSAL), IRCCS San Martino University Hospital, Genoa, Italy
  • Giacomo Caldarola Section of Dermatology, Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart; Dermatology Unit, Agostino Gemelli University Polyclinic Foundation, IRCCS, Rome, Italy
  • Anna Campanati Department of Clinical and Molecular Sciences - Dermatological Clinic, Università Politecnica delle Marche, Ancona, Italy
  • Elena Campione Dermatology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
  • Carlo G. Carrera Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
  • Andrea Carugno Dermatology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo; Molecular and Translational Medicine (DIMET), University of Milan-Bicocca, Milan, Italy
  • Francesco Cusano Department of Dermatology, Gaetano Rummo Hospital, Benevento, Italy
  • Paolo Dapavo Department of Biomedical Science and Human Oncology, Second Dermatologic Clinic, University of Turin, Turin, Italy
  • Annunziata Dattola Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, Rome, Italy
  • Clara De Simone Section of Dermatology, Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart; Dermatology Unit, Agostino Gemelli University Polyclinic Foundation, IRCCS, Rome, Italy
  • Valentina Dini Dermatology Unit, Department of Clinical and Experimental Medicine, Ospedale Santa Chiara, Pisa, Italy
  • Maria Esposito Dermatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy
  • Maria C. Fargnoli Dermatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy
  • Francesca M. Gaiani Department of Dermatology, Dermatology Unit Azienda Ospedaliera San Donato Milanese, Milan, Italy
  • Luigi Gargiulo Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
  • Paolo Gisondi Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy
  • Alessandro Giunta Dermatology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
  • Luciano Ibba Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
  • Claudia Lasagni Dermatological Clinic, Department of Specialized Medicine, University of Modena, Modena, Italy
  • Francesco Loconsole Department of Dermatology, University of Bari, Bari, Italy
  • Vincenzo Maione Department of Dermatology, ASST Spedali Civili Hospital, Brescia, Italy
  • Edoardo Mortato Department of Dermatology, University of Bari, Bari, Italy
  • Angelo V. Marzano Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
  • Martina Maurelli Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy
  • Matteo Megna Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
  • Santo R. Mercuri Unit of Dermatology and Cosmetology, IRCCS San Raffaele Scientific Institute; Università Vita-Salute San Raffaele, Milan, Italy
  • Alessandra Narcisi Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
  • Annamaria Offidani Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
  • Giovanni Paolino Unit of Dermatology and Cosmetology, IRCCS San Raffaele Scientific Institute, Milan, Italy
  • Aurora Parodi Section of Dermatology, Department of Health Sciences (DISSAL), IRCCS San Martino University Hospital, Genoa, Italy
  • Giovanni Pellacani Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, Rome, Italy
  • Luca Potestio Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
  • Pietro Quaglino Department of Biomedical Science and Human Oncology, Second Dermatologic Clinic, University of Turin, Turin, Italy
  • Antonio G. Richetta Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, Rome, Italy
  • Francesca Romano Dermatology Unit, AORN “A. Cardarelli”, Naples, Italy
  • Paolo Sena Dermatology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy
  • Marina Venturini Department of Dermatology, ASST Spedali Civili Hospital, Brescia, Italy
  • Chiara Assorgi Clinical Dermatology Unit, San Gallicano Dermatological Institute IRCCS, Rome; Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
  • Antonio Costanzo Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy

Keywords:

immunomodulatory therapies, inflammatory skin diseases, psoriasis, psoriasis treatment

Abstract

Introduction: Genital involvement is observed in approximately 60% of patients with psoriasis, presenting clinicians with formidable challenges in treatment. While new biologic drugs have emerged as safe and effective options for managing psoriasis, their efficacy in challenging-to-treat areas remains inadequately explored. Intriguingly, studies have shown that interleukin (IL)-17 inhibitors exhibit effectiveness in addressing genital psoriasis.

Objectives: We aimed to determine the effectiveness profile of bimekizumab in patients affected by moderate-to-severe plaque psoriasis with involvement of genitalia.

Methods: Bimekizumab, a dual inhibitor of both IL-17A and IL-17F, was the focus of our 16-week study, demonstrating highly favorable outcomes for patients with genital psoriasis. The effectiveness of bimekizumab was evaluated in terms of improvement in Static Physician's Global Assessment of Genitalia (sPGA-G) and Psoriasis Area and Severity Index.

Results: Sixty-five adult patients were enrolled. Remarkably, 98.4% of our participants achieved a clear sPGA-G score (s-PGA-g=0) within 16 weeks. Moreover, consistent improvements were observed in PASI scores, accompanied by a significant reduction in the mean Dermatology Life Quality Index (DLQI), signifying enhanced quality of life. Notably, none of the patients reported a severe impairment in their quality of life after 16 weeks of treatment.  In our cohort of 65 patients, subgroup analyses unveiled that the effectiveness of bimekizumab remained unaffected by prior exposure to other biologics or by obesity.

Conclusions: Our initial findings suggest that bimekizumab may serve as a valuable treatment option for genital psoriasis. Nevertheless, further research with larger sample sizes and longer-term follow-up is imperative to conclusively validate these results.

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Bimekizumab for the Treatment of Plaque Psoriasis With Involvement of Genitalia: A 16-Week Multicenter Real-World Experience—IL PSO (Italian Landscape Psoriasis). Dermatol Pract Concept [Internet]. [cited 2024 Apr. 12];14(2):e2024052. Available from: https://dpcj.org/index.php/dpc/article/view/4194

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Bimekizumab for the Treatment of Plaque Psoriasis With Involvement of Genitalia: A 16-Week Multicenter Real-World Experience—IL PSO (Italian Landscape Psoriasis). Dermatol Pract Concept [Internet]. [cited 2024 Apr. 12];14(2):e2024052. Available from: https://dpcj.org/index.php/dpc/article/view/4194

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