Significance of Primary Melanoma Regression on Local Infiltrate and Outcome

Significance of Primary Melanoma Regression on Local Infiltrate and Outcome

Authors

  • Awatef Kelati Dermatology Department, Hôpital Universitaire Lyon Sud, Hospices Civils de Lyon. Pierre-Bénite, France ; Dermatology Department, Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco
  • Brigitte Balme Anatomo-Pathology Department, Hôpital Universitaire Lyon Sud, Hospices Civils de Lyon. Pierre-Bénite, France
  • Brigitte Chouvet Anatomo-Pathology Department, Hôpital Universitaire Lyon Sud, Hospices Civils de Lyon. Pierre-Bénite, France
  • Alexandra Traverse-Glehen Anatomo-Pathology Department, Hôpital Universitaire Lyon Sud, Hospices Civils de Lyon. Pierre-Bénite, France
  • Juliette Tantot Anatomo-Pathology Department, Hôpital Universitaire Lyon Sud, Hospices Civils de Lyon. Pierre-Bénite, France
  • Olivier Harou Anatomo-Pathology Department, Hôpital Universitaire Lyon Sud, Hospices Civils de Lyon. Pierre-Bénite, France
  • Gérard Duru Research director in the Claude Bernard University, Lyon, France
  • Sebastien Debarbieux Dermatology Department, Hôpital Universitaire Lyon Sud, Hospices Civils de Lyon. Pierre-Bénite, France
  • Stephane Dalle Dermatology Department, Hôpital Universitaire Lyon Sud, Hospices Civils de Lyon. Pierre-Bénite, France; Lyon 1 University Lyon France; Lyon Cancer Research Center, Centre Léon Bérard Lyon France
  • Luc Thomas Dermatology Department, Hôpital Universitaire Lyon Sud, Hospices Civils de Lyon. Pierre-Bénite, France; Lyon 1 University Lyon France; Lyon Cancer Research Center, Centre Léon Bérard Lyon France

Keywords:

primary melanoma, local infiltrate, outcome, histopathology, dermoscopy

Abstract

Introduction: The characteristics and the prognostic value of regression in primary melanomas are controversial.

Objectives: To further characterize “hot” and “cold” tumor’s stromas and to investigate the association between dermoscopy, pathology, and the prognostic implications of regression.

Methods: A 14-year-collection-based retrospective analysis was carried out on 40 patients with confirmed regressive melanomas.

Results: The extent of regression in dermoscopy was associated with the stage of the regression (P = 0.05) and with the MelanA patterns in histology (P = 0.02). Blue-gray and gray-brown color of the peppering (P = 0.01), and  the eccentric, multifocal character of the dermoscopic regression (P = 0.05) were associated with “hot” stromas (CD8+, Granzym B+). Focal histologic regression (regressing melanomas) was associated with a good outcome (P < 0.001), while a complete regression (regressed melanomas) was associated with melanoma-related death (P < 0.001). “Hot” stromas (CD8+ were significantly associated with survival at 10 years (P = 0.044), while “hot” stromas (Granzyme B+) were associated with the locoregional extension (P = 0.016), and the initial distant metastasis (P = 0.016).

Conclusions: Dermoscopic features of regression in primary melanomas were associated with the stage of regression, its extent, and the “hot” or “cold” nature of the tumor stroma, with prognostic implications.

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Published

2022-02-02

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Original Article

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1.
Significance of Primary Melanoma Regression on Local Infiltrate and Outcome. Dermatol Pract Concept [Internet]. 2022 Feb. 2 [cited 2024 Apr. 23];12(1):e2022034. Available from: https://dpcj.org/index.php/dpc/article/view/1842

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