Atopic Dermatitis Pathogenesis: Lessons From Immunology

Atopic Dermatitis Pathogenesis: Lessons From Immunology

Authors

  • Luis Santamaria-Babi Translational Immunology, Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Parc Científic de Barcelona, Barcelona, Spain

Abstract

Translational research has changed the understanding of AD pathogenesis beyond basic mechanisms of immunology. The study in patients of rational therapies based on targeted therapies (biologicals) provides valuable information from the patient and provides lessons of clinical immunology on clinically relevant mechanism of AD pathogenesis. AD features such as skin barrier defect, skin dysbiosis, and pruritus share a common abnormal adaptive immune response process. Skin related skin-homing CLA+CD4+ memory T cells produce IL-4, IL-13, and IL-31 which are key mediators in AD pathogenesis. Lessons learned from AD is that translation immunology allows generating rational therapies for AD and learning the immunopathogenesis in the patient

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Published

2022-02-02

Issue

Section

Review

How to Cite

1.
Atopic Dermatitis Pathogenesis: Lessons From Immunology. Dermatol Pract Concept [Internet]. 2022 Feb. 2 [cited 2024 Apr. 23];12(1):e2022152. Available from: https://dpcj.org/index.php/dpc/article/view/2300

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