Mortality Of Malignant Melanoma In Central Serbia, In The Period 1999-2015

Mortality Of Malignant Melanoma In Central Serbia, In The Period 1999-2015

Authors

  • Milica Pantovic Clinical Hospital Center Zemun, Belgrade, Serbia
  • Ognjen Djordjevic University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Hygiene and ecology
  • Svetlana Radevic Department of Social medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  • Dragic Bankovic Faculty of Science, University of Kragujevac, Kragujevac, Serbia
  • Katarina Parezanovic Ilic University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Physical medicine and rehabilitation
  • Snezana Radovanovic University of Kragujevac, Serbia, Faculty of Medical Sciences, Department of Social medicine

Keywords:

malinant melanoma, mortality, risk factors, Serbia

Abstract

Introduction: Malignant melanoma is one of the rarest but the most deadly form of skin cancer.

Objective: The objective of this paper was to analyze the epidemiological characteristics and trends of mortality from malignant melanoma of the population of Central Serbia in the period 1999-2015.

Methods:  The study was designed as a retrospective descriptive epidemiological study. Standardized mortality rates were used in statistical data processing.  A linear trend model and regression analysis were used to examine trends in malignant melanoma mortality.

Results:  In Serbia, malignant melanoma mortality shows an increasing trend. The overall age-adjusted melanoma death rate was 2.6 per 100 000 with a higher death rate among men (3.03per 100 000) than among women (2.1 per 100 000). Malignant melanoma mortality rates increase with age in both sexes and are highest in the age group of 75 and older. The highest increase in mortality in men is recorded in the age group of 65-69 years, with an average percentage increase of 21.33 (95% CI, 8.40 - 51.05), while in women the largest increase in mortality was recorded in the age group 35-39 years, with an average percentage increase of 31.4  and in the age group of 70-74 years, 12.9 .

Conclusions: The trend of increasing mortality from malignant melanoma in Serbia is similar to those in most developed countries. Education and improvement of the awareness of the general population and among health professionals remain vital to reducing melanoma mortality in the future.

References

GLOBOCAN 2020. Cancer Incidence and Mortality Worldwide. Accessed March 19, 2020. Available from: http:// https://gco.iarc.fr/

Gutiérrez-González E, López-Abente G, Aragonés N, et al. Trends in mortality from cutaneous malignant melanoma in Spain (1982-2016): sex-specific age-cohort-period effects. J Eur Acad Dermatol Venereol. 2019;33(8):1522‐1528. DOI: 10.1111/jdv.15565

McKenna MR, Stobaugh DJ, Deepak P. Melanoma and non-melanoma skin cancer in inflammatory bowel disease patients following tumor necrosis factor-α inhibitor monotherapy and in combination with thiopurines: analysis of the Food and Drug Administration Adverse Event Reporting System. J Gastrointestin Liver Dis. 2014;23:267-271. DOI: 10.15403/jgld.2014.1121.233.mrmk

Nikolaou V, Stratigos AJ. Emerging trends in the epidemiology of melanoma. Br J Dermatol. 2014;170(1):11–19. DOI: 10.1111/bjd.12492 PMID: 23815297

Guy GP Jr, Thomas CC, Thompson T, Watson M, Massetti GM, Richardson LC. Vital signs: Melanoma incidence and mortality trends and projections – United States, 1982–2030. MMWR Morb Mortal Wkly Rep. 2015;64(21):591–6.) PMID: 26042651

Kaminska-Winciorek G, Wydmanski J, Gajda M, Tukiendorf A. Melanoma awareness and prevalence of dermoscopic examination among internet users: a cross-sectional survey. Postepy Dermatol Alergol. 2016;33(6):421-428. DOI:10.5114/pdia.2016.63297

GLOBOCAN 2020. Cancer Incidence and Mortality Worldwide. Accessed March 19, 2020. Available from: http:// https://gco.iarc.fr/

Boyers LN, Karimkhani C, Naghavi M, et al. Global mortality from conditions with skin manifestations. J Am Acad Dermatol. 2014; 2. pii: S0190-9622(14)01869-6. DOI: https://doi.org/10.1016/j.jaad.2014.08.022

Lin L, Yan L, Liu Y, Yuan F, Li H, Ni J. Incidence and death in 29 cancer groups in 2017 and trend analysis from 1990 to 2017 from the Global Burden of Disease Study. J Hematol Oncol. 2019;12(1):96. DOI: 10.1186/s13045-019-0783-9

Sneyd MJ, Cox B. A comparison of trends in melanoma mortality in New Zealand and Australia: the two countries with the highest melanoma incidence and mortality in the world. BMC Cancer. 2013;13:372. DOI: 10.1186/1471-2407-13-372

Ghazawi FM, Le M, Lagacé F, et al. Incidence, Mortality, and Spatiotemporal Distribution of Cutaneous Malignant Melanoma Cases Across Canada. J Cutan Med Surg. 2019;23(4):394‐412. DOI: 10.1177/1203475419852048 PMID: 31132871

Jemal A, Saraiya M, Patel P, Cherala SS, Barnholtz-Sloan J, Kim J, et al. Recent trends in cutaneous melanoma incidence and death rates in the United States, 1992-2006. J Am Acad Dermatol. 2011; 65: e17. DOI: 10.1016/j.jaad.2011.04.032 PMID: 22018063

Iannacone MR, Youlden DR, Baade PD, Aitken JF, Green AC. Melanoma incidence trends and survival in adolescents and young adults in Queensland, Australia. Int J Cancer. 2015;136(3):603‐609. DOI: 10.1002/ijc.28956 PMID: 24806428

Puig-Butille JA, Escámez MJ, Garcia-Garcia F, et al. Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer. Oncotarget. 2014;5(6):1439-1451. DOI:10.18632/oncotarget.1444

Gandini S, Sera F, Cattaruzza MS, et al. Meta-analysis of risk factors for cutaneous melanoma: III. Family history, actinic damage and phenotypic factors. Eur J Cancer. 2005;41(14):2040-2059. DOI: 10.1016/j.ejca.2005.03.034 PMID: 16125929

Leiter U, Garbe C. Epidemiology of melanoma and nonmelanoma skin cancer--the role of sunlight. Adv Exp Med Biol 2008;624:89-103. DOI: 10.1007/978-0-387-77574-6_8 PMID: 18348450

Leiter U, Eigentler T, Garbe C. Epidemiology of skin cancer. Adv Exp Med Biol. 2014;810:120‐140. DOI: 10.1007/978-1-4939-0437-2_7 PMID: 25207363

International Agency for Research on Cancer. Cancer Mortality Database. Accessed March 9, 220. Available from: https://www-dep.iarc.fr/WHOdb/WHOdb.htm

Whiteman DC, Green AC, Olsen CM. The growing burden of invasive melanoma: Projections of incidence rates and numbers of new cases in six susceptible populations through 2031. J Investig Dermatol. 2016;136(6):1161–71. DOI:10.1016/j.jid.2016.01.035 PMID: 26902923

Watson M, Geller AC, Tucker MA, Guy GP Jr, Weinstock MA. Melanoma burden and recent trends among non-Hispanic whites aged 15–49 years, United States. Prev Med. 2016;91:294–8. DOI: 10.1016/j.ypmed.2016.08.032 PMID: 27565055

Garbe C, Leiter U. Melanoma epidemiology and trends. Clin Dermatol. 2009;27(1):3–9. DOI: 10.1016/j.clindermatol.2008.09.001 PMID: 19095149

Aitken JF, Youlden DR, Baade PD, Soyer HP, Green AC, Smithers BM. Generational shift in melanoma incidence and mortality in Queensland, Australia, 1995-2014. Int J Cancer. 2018;142(8):1528‐1535. DOI: 10.1002/ijc.31141 PMID: 29105744

Khosrotehrani K, Dasgupta P, Byrom L, Youlden DR, Baade PD, Green AC. Melanoma survival is superior in females across all tumour stages but is influenced by age. Arch Dermatol Res. 2015;307(8):731–40. DOI: 10.1007/s40487-020-00109-1 PMID: 32700073

Ferlay J, Colombet M, Soerjomataram I, et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer. 2018;103:356‐387. DOI: 10.1016/j.ejca.2018.07.005 PMID: 30100160

Weir HK, Marrett LD, Cokkinides V, Barnholtz-Sloan J, Patel P, Tai E, et al. Melanoma in adolescents and young adults (ages 15–39 years): United States, 1999–2006. J Am Acad Dermatol. 2011;65(5) Suppl 1:S38–49. DOI: 10.1016/j.jaad.2011.04.038 PMID: 22018066

Li WQ, Cho E, Weinstock MA, Mashfiq H, Qureshi AA. Epidemiological assessments of skin outcomes in the nurses’ health studies. Am J Public Health. 2016;106(9):1677–83. DOI: 10.2105/AJPH.2016.303315 PMID: 27459457

Erdei E, Torres SM. A new understanding in the epidemiology of melanoma. Expert Rev Anticancer Ther. 2010;10(11):1811‐1823. DOI: 10.1586/era.10.170 PMID: 21080806

Schmidt A, Nanney LB, Boyd AS, King LE, Ellis DL. Oestrogen receptor-β expression in melanocytic lesions. Exp Dermatol. 2006;15:971–980. DOI: 10.1111/j.1600-0625.2006.00502.x PMID: 17083364

Koomen ER, Joosse A, Herings, et al. Estrogens, oral contraceptives and hormonal replacement therapy increase the incidence of cutaneous melanoma: a population-based case–control study. Ann Oncol. 2009;20(2):358–364. DOI: 10.1093/annonc/mdn589 PMID: 18725391

Karimkhani C, Green AC, Nijsten T, et al. The global burden of melanoma: results from the Global Burden of Disease Study 2015. Br J Dermatol. 2017;177(1):134‐140. DOI: 10.1111/bjd.15510 PMID: 28369739

Lasithiotakis KG, Petrakis IE, Garbe C. Cutaneous melanoma in the elderly: epidemiology, prognosis and treatment. Melanoma Res. 2010;20(3):163-70. DOI: 10.1097/CMR.0b013e328335a8dd PMID: 20375923

National Cancer Institute Surveillance, Epidemiology, and End Results Program. Cancer Stat Facts: Melanoma of the Skin. Available from: https://seer.cancer.gov/statfacts/html/melan.html.

Veierod MB, Adami HO, Lund E, Armstrong BK, Weiderpass E. Sun and solarium exposure and melanoma risk: effects of age, pigmentary characteristics, and nevi. Cancer Epidemiol Biomarkers Prev. 2010;19(1):111-120. DOI: 10.1158/1055-9965.EPI-09-0567 PMID: 20056629

Armstrong BK. How sun exposure causes skin cancer: An epidemiological perspective In: Hill D, Elwood JM, English D. Prevention of Skin Cancer. Dordrecht, The Netherlands: Kluwer Academic Publishers, 2004: 89-116.

Kricker A, Armstrong BK, Goumas C, et al. Ambient UV, personal sun exposure and risk of multiple primary melanomas. Cancer Causes Control 2007;18(3):295-304. DOI: 10.1007/s10552-006-0091-x PMID: 17206532

Pfahlberg A, Kölmel KF, Gefeller O; Febim Study Group. Timing of excessive ultraviolet radiation and melanoma: epidemiology does not support the existence of a critical period of high susceptibility to solar ultraviolet radiation- induced melanoma. Br J Dermatol. 2001;144(3):471‐475. DOI: 10.1046/j.1365-2133.2001.04070.x PMID: 11260001

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Published

2023-01-31

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Section

Original Article

How to Cite

1.
Pantovic M, Djordjevic O, Radevic S, Bankovic D, Parezanovic Ilic K, Radovanovic S. Mortality Of Malignant Melanoma In Central Serbia, In The Period 1999-2015. Dermatol Pract Concept. 2023;13(1):e2023008. doi:10.5826/dpc.1301a8

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