The Role of Ischemia-modified Albumin and Ischemia-modified Albumin to Albumin Ratios in Patients with Alopecia Areata
Keywords:
Alopecia areata, ischemia-modified albumin, IMA/albumin, disease severityAbstract
Objective: To investigate the role of ischemia-modified albumin (IMA) and IMA/albumin levels in patients with AA.
Methods: The present prospective crossectional study includes patients ≥ 18 who admitted to the Dermatology and Venerology Department of XXXX University Hospital between April 1 2021, and September 30 2021. 70 patients participated in the study (n=34 for the study group and n=36 for the control group). Demographic features, clinical characteristics, IMA, and IMA/albumin levels were compared between the groups. Study group was divided into subgroups based on the number of patches, disease duration, and number of disease attacks. IMA and IMA/albumin levels were compared between each subgroup.
Results: Study and control groups were similar with regard to demographic features and clinical characteristics. Significant differences were observed between the mean IMA and IMA /albumin ratio (p=0.004 and 0.012, respectively). The study subgroups were comparable for the number of patches, disease duration and number of disease attack.
Conclusion: Although oxydative stress is an important component in the etiology of AA, IMA and IMA/albumin may not be useful in the prediction of disease severity in patients with AA.
References
Strazzulla LC, Wang EHC, Avila L, et al. Alopecia areata: disease characteristics, clinical evaluation, and new perspectives on pathogenesis. Journal of the American Academy of Dermatology. 2018;78(1):1-12.
Rajabi F, Drake LA, Senna MM, Rezaei N. Alopecia areata: a review of disease pathogenesis. Br J Dermatol. 2018;179(5):1033-1048.
Simakou T, Butcher JP, Reid S, Henriquez FL. Alopecia areata: A multifactorial autoimmune condition. Journal of autoimmunity. 2019;98:74-85.
Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes–review and clinical implications. Clinical Chemistry and Laboratory Medicine. 2011;49(2):177-184.
Dominguez-Rodriguez A, Abreu-Gonzalez P. Current role of ischemia-modified albumin in routine clinical practice. Biomarkers. 2010;15(8):655-662.
Türedi S, Şahin A, Akça M, et al. Ischemia-modified albumin and the IMA/albumin ratio in the diagnosis and staging of hemorrhagic shock: A randomized controlled experimental study. Turkish Journal of Trauma and Emergency Surgery. 2020;26(2):153-162.
Işik S, Kılıç S, Öğretmen Z, et al. The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii. 2016;33(4):290.
Kılıç S, Işık S, Hiz MM, et al. The ischemia modified albumin and mean platelet volume levels in patients with Behçet’s disease. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii. 2016;33(5):345.
Incel-Uysal P, Akdogan N, Alli N, et al. Assessment of metabolic profile and ischemia-modified albumin level in patients with alopecia areata: A case–control study. Indian journal of dermatology. 2019;64(1):12.
Sachdeva S, Khurana A, Goyal P, Sardana K. Does oxidative stress correlate with disease activity and severity in alopecia areata? An analytical study. J Cosmet Dermatol. 2021.
Mustafa AI, Khashaba RA, Fawzy E, Baghdady SMA, Rezk SM. Cross talk between oxidative stress and inflammation in alopecia areata. J Cosmet Dermatol. 2021;20(7):2305-2310.
Peluso I, Cavaliere A, Palmery M. Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis. J Biomed Sci. 2016;23(1):52.
Qiu L, Song Z, Setaluri V. Oxidative stress and vitiligo: the Nrf2-ARE signaling connection. J Invest Dermatol. 2014;134(8):2074-2076.
Shah AA, Dey-Rao R, Seiffert-Sinha K, Sinha AA. Increased oxidative stress in pemphigus vulgaris is related to disease activity and HLA-association. Autoimmunity. 2016;49(4):248-257.
Emre S, Metin A, Demirseren DD, et al. The association of oxidative stress and disease activity in seborrheic dermatitis. Arch Dermatol Res. 2012;304(9):683-687.
Narendhirakannan RT, Hannah MA. Oxidative stress and skin cancer: an overview. Indian J Clin Biochem. 2013;28(2):110-115.
Okayama Y. Oxidative stress in allergic and inflammatory skin diseases. Curr Drug Targets Inflamm Allergy. 2005;4(4):517-519.
Akar A, Arca E, Erbil H, Akay C, Sayal A, Gür AR. Antioxidant enzymes and lipid peroxidation in the scalp of patients with alopecia areata. Journal of dermatological science. 2002;29(2):85-90.
Naziroglu M, Kokcam I. Antioxidants and lipid peroxidation status in the blood of patients with alopecia. Cell Biochemistry and Function: Cellular biochemistry and its modulation by active agents or disease. 2000;18(3):169-173.
Abdel Fattah N, Ebrahim A, El Okda E. Lipid peroxidation/antioxidant activity in patients with alopecia areata. Journal of the European Academy of Dermatology and Venereology. 2011;25(4):403-408.
Zhong Y, Wang N, Xu H, Hou X, Xu P, Zhou Z. Ischemia-modified albumin in stable coronary atherosclerotic heart disease: clinical diagnosis and risk stratification. Coronary Artery Disease. 2012;23(8):538-541.
Ellidag HY, Eren E, Aydin O, et al. Ischemia modified albumin levels and oxidative stress in patients with bladder cancer. Asian Pacific Journal of Cancer Prevention. 2013;14(5):2759-2763.
Ahn JH, Choi SC, Lee WG, Jung YS. The usefulness of albumin-adjusted ischemia-modified albumin index as early detecting marker for ischemic stroke. Neurological sciences. 2011;32(1):133-138.
Hogg K, Hinchliffe E, Halsam S, Valkov A, Lecky F. Is ischaemia-modified albumin a test for venous thromboembolism? Emergency Medicine Journal. 2012;29(6):455-459.
Shakoei S, Ghiasi M, Ziaee K. Coagulation status in patients with alopecia areata: a cross-sectional study. G Ital Dermatol Venereol. 2020.
Kang J-H, Lin H-C, Kao S, Tsai M-C, Chung S-D. Alopecia areata increases the risk of stroke: a 3-year follow-up study. Scientific reports. 2015;5(1):1-6.
Lee H, Kim YC, Choi JW. Alopecia areata is not a risk factor for heart diseases: A 10-year retrospective cohort study. Plos one. 2021;16(5):e0250216.
Huang KP, Joyce CJ, Topaz M, Guo Y, Mostaghimi A. Cardiovascular risk in patients with alopecia areata (AA): A propensity-matched retrospective analysis. Journal of the American Academy of Dermatology. 2016;75(1):151-154.
Shoeib MA, Bakry OA, Soliman SE, Iraqi AS. Troponin I in alopecia areata and female pattern hair loss. Menoufia Medical Journal. 2021;34(2):498.
El‐Sayed Mahmoud Marie R, El‐Sayed G, Attia F, Gomaa A. Evaluation of serum cardiac troponin I and N‐terminal pro‐B‐type natriuretic peptide levels in patients with alopecia areata. Clinical and Experimental Dermatology. 2021;46(1):153-156.
Ataş H, Gönül M, Öztürk Y, Kavutcu M. Ischemic modified albumin as a new biomarker in predicting oxidative stress in alopecia areata. Turkish journal of medical sciences. 2019;49(1):129-138.
Acharya P, Mathur MC. Oxidative stress in alopecia areata: a systematic review and meta‐analysis. International journal of dermatology. 2020;59(4):434-440.
Yavuz F, Biyik M, Asil M, et al. Serum ischemic modified albumin (IMA) concentration and IMA/albumin ratio in patients with hepatitis B-related chronic liver diseases. Turkish journal of medical sciences. 2017;47(3):947-953.
Amin SS, Sachdeva S. Alopecia areata: A review. Journal of the Saudi Society of Dermatology & Dermatologic Surgery. 2013;17(2):37-45.
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