Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris
Keywords:
acne vulgaris, oxidative stress, thiols, IMAAbstract
Introduction: Acne vulgaris (AV) is the most common skin disease. AV is a skin disease often associated with oxidative stress. Thiols and ischemia modified albumin (IMA) analysis are used as oxidative stress markers.
Objectives: In this study, it was aimed to evaluate the blood levels of thiols and IMA, which are accepted as oxidative stress markers, and to determine the severity of the disease in AV patients whose severity is determined by the global acne score rate (GAS).
Methods: Thiol parameters and IMA values were measured spectrophotometrically in blood samples taken from patients and controls. Determine VAS values in AV patients. The thiol and IMA values obtained were compared between the patient and control groups and their correlation with the patient's VAS values was evaluated.
Results: In our study, in acne patients, native thiol (NT), total thiol (TT) and index 3 (I3=NT/TT*100) were significantly lower than the control group, disulfide (SS), index 1 (I1=SS/NT*100), index 2 (I2=SS/TT*100) and IMA values were found to be significantly higher. GAS values, which are accepted as an indicator of the degree and severity of acne disease, and SS, I1 and I2 showed a positive correlation, while I3 showed a negative correlation.
Conclusion: Our study suggests that oxidative stress associated with AV disease pathogenesis may occur through mechanisms dependent on thiol and IMA levels. Therefore, in AV, oral supplementation or topical application of antioxidants may be a good way to increase drug efficacy or prevent potential harm.
References
Zouboulis CC. Acne as a chronic systemic disease. Clin Dermatol. 2014;32(3):389-396. DOI: 10.1016/j.clindermatol.2013.11.005. PMID: 24767186.
Al-Shobaili HA. Oxidants and anti-oxidants status in acne vulgaris patients with varying severity. Ann Clin Lab Sci. 2014;44(2):202-207. PMID: 24795060.
Al-Shobaili HA, Alzolibani AA, Al Robaee AA, Meki ARMA, Rasheed Z. Biochemical Markers of Oxidative and Nitrosative Stress in Acne Vulgaris: Correlation With Disease Activity. J Clin Lab Anal. 2013;27(1):45-52. DOI:10.1002/jcla.21560. PMID: 23325743.
Perihan O, Ergul KB, Neslihan D, Filiz A. The activity of adenosine deaminase and oxidative stress biomarkers in scraping samples of acne lesions. J Cosmet Dermatol. 2012;11(4):323-328. DOI:10.1111/jocd.12011. PMID: 23174057.
Yang YS, Lim HK, Hong KK, et al. Cigarette Smoke-Induced Interleukin-1 Alpha May Be Involved in the Pathogenesis of Adult Acne. Ann Dermatol. 2014;26(1):11. DOI:10.5021/ad.2014.26.1.11. PMID: 24648681.
Bowe WP, Logan AC. Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles. Lipids Health Dis. 2010;9(1):141. DOI:10.1186/1476-511X-9-141. PMID: 21143923.
Kardeh S, Moein SA, Namazi MR, Kardeh B. Evidence for the Important Role of Oxidative Stress in the Pathogenesis of Acne. Galen Med J. 2019;8:e1291. DOI:10.31661/gmj.v0i0.1291. PMID: 34466486.
Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes – review and clinical implications. Clin Chem Lab Med. 2011;49(2). DOI:10.1515/CCLM.2011.037. PMID: 21083441.
Erel Ö, Erdoğan S. Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects. Turk J Med Sci. 2020;50(7):1728-1738. DOI:10.3906/sag-2003-64. PMID: 32233181.
Bilaç C, Şahin MT, Öztürkcan S. Disease severity scoring systems in dermatology. TURKDERM. 2016;50(2):42-53. DOI:10.4274/turkderm.67799.
Doshi A, Zaheer A, Stiller M. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997;36(6):416-418. DOI:10.1046/j.1365-4362.1997.00099.x. PMID: 9248884.
Bar–Or D, Lau E, Winkler J V. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia—a preliminary report. J Emerg Med. 2000;19(4):311-315. DOI:10.1016/S0736-4679(00)00255-9. PMID: 11074321.
Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem. 2014;47(18):326-332. DOI:10.1016/j.clinbiochem.2014.09.026. PMID: 25304913.
Tan JKL, Stein Gold LF, Alexis AF, Harper JC. Current Concepts in Acne Pathogenesis: Pathways to Inflammation. Semin Cutan Med Surg. 2018;37(3S):S60-S62. DOI:10.12788/J.SDER.2018.024. PMID: 30192343.
Kircik LH. Advances in the Understanding of the Pathogenesis of Inflammatory Acne. J Drugs Dermatol. 2016;15(1 Suppl 1):s7-10. PMID: 26741394.
Briganti S, Picardo M. Antioxidant activity, lipid peroxidation and skin diseases. What’s new. J Eur Acad Dermatol Venereol. 2003;17(6):663-669. DOI:10.1046/j.1468-3083.2003.00751.x. PMID: 14761133.
Öztas MO, Balk M, Ögüs E, Bozkurt M, Ögüs IH, Özer N. The role of free oxygen radicals in the aetiopathogenesis of rosacea. Clin Exp Dermatol. 2003;28(2):188-192. DOI:10.1046/j.1365-2230.2003.01179.x. PMID: 12653711.
Baek J, Lee MG. Oxidative stress and antioxidant strategies in dermatology. Redox Report. 2016;21(4):164-169. DOI:10.1179/1351000215Y.0000000015. PMID: 2602052.
Akamatsu H, Horio T, Hattori K. Increased hydrogen peroxide generation by neutrophils from patients with acne inflammation. Int J Dermatol. 2003;42(5):366-369. DOI:10.1046/j.1365-4362.2003.01540.x. PMID: 12755973.
Brown SK, Shalita AR. Acne vulgaris. The Lancet. 1998;351(9119):1871-1876. DOI:10.1016/S0140-6736(98)01046-0. PMID: 9652685.
Choi C, Lee D, Kim H, Kim B, Park K, Youn S. The clinical features of late onset acne compared with early onset acne in women. J Eur Acad Dermatol Venereol. 2011;25(4):454-461. DOI:10.1111/j.1468-3083.2010.03813.x. PMID: 20659307.
Arican O, Kurutas EB, Sasmaz S. Oxidative stress in patients with acne vulgaris. Mediators Inflamm. 2005;2005(6):380-384. DOI:10.1155/MI.2005.380. PMID: 20659307.
Kardeh S, Moein SA, Namazi MR, Kardeh B. Evidence for the Important ¬Role of Oxidative Stress in the Pathogenesis of Acne. Galen Med J. 2019;8:1291. DOI:10.31661/gmj.v8i0.1291. PMID: 34466486.
Basak PY, Gultekin F, Kilinc I. The Role of the Antioxidative Defense System in Papulopustular Acne. J Dermatol. 2001;28(3):123-127. DOI:10.1111/j.1346-8138.2001.tb00105.x. PMID: 11349462.
El-akawi Z, Abdel-Latif N, Abdul-Razzak K. Does the plasma level of vitamins A and E affect acne condition? Clin Exp Dermatol. 2006;31(3):430-434. DOI:10.1111/j.1365-2230.2006.02106.x. PMID: 16681594.
Awad SM, Morsy H, Sayed AA, Mohamed NA, Ezzat GM, Noaman MM. Oxidative stress and psychiatric morbidity in patients with facial acne. J Cosmet Dermatol. 2018;17(2):203-208. DOI:10.1111/jocd.12366. PMID: 28631890.
Sarici G, Cinar S, Armutcu F, Altınyazar C, Koca R, Tekin N. Oxidative stress in acne vulgaris. J Eur Acad Dermatol Venereol. 2009;24(7):763-767. DOI:10.1111/j.1468-3083.2009.03505.x. PMID: 19943837.
Moazen M, Mazloom Z, Jowkar F, Nasimi N, Moein Z. Vitamin D, Adiponectin, Oxidative Stress, Lipid Profile, and Nutrient Intakes in the Females with Acne Vulgaris: A Case-Control Study. Galen Med. J. 2019;8:1515. DOI:10.31661/gmj.v8i0.1515. PMID: 34466520.
Dogru A, Balkarli A, Cetin GY, et al. Thiol/disulfide homeostasis in patients with ankylosing spondylitis. Bosn J Basic Med Sci. 2016;16(3):187-192. DOI:10.17305/bjbms.2016.1001. PMID: 27186972.
Kundi H, Erel Ö, Balun A, et al. Association of thiol/disulfide ratio with syntax score in patients with NSTEMI. Scand Cardiovasc J. 2015;49(2):95-100. DOI: 10.3109/14017431.2015.1013153. PMID: 25658436.
Kaplan M, Ates I, Yuksel M, et al. Thiol/disulphide homeostasis in celiac disease. World J Gastrointest Pharmacol Ther. 2017;8(2):120. DOI:10.4292/wjgpt.v8.i2.120. PMID: 28533921.
Georgescu SR, Mitran CI, Mitran MI, et al. Thiol-Disulfide Homeostasis in Skin Diseases. J Clin Med. 2022;11(6). DOI:10.3390/jcm11061507. PMID: 35329832.
Gürel G. Evaluation of thiol/disulfide homeostasis in patients with acne vulgaris. J Clin Anal Med. 2019;10(02). DOI:10.4328/JCAM.5852.
Sinha MK, Vazquez JM, Calvino R, Gaze DC, Collinson PO, Kaski JC. Effects of balloon occlusion during percutaneous coronary intervention on circulating Ischemia Modified Albumin and transmyocardial lactate extraction. Heart. 2006;92(12):1852-1853. DOI:10.1136/hrt.2005.078089. PMID: 17105887.
Tampa M, Mitran CI, Mitran MI, Amuzescu A, Matei C, Georgescu SR. Ischemia-Modified Albumin-A Potential New Marker of Oxidative Stress in Dermatological Diseases. Medicina (Kaunas). 2022;58(5). DOI:10.3390/medicina58050669. PMID: 35630086.
Gürel G, Karadöl M, Bal C, Neselioğlu S, Çölgeçen E. Evaluation of ischemia-modified albumin levels in acne vulgaris patients. TURKDERM. 2019;53(3):84-87. DOI:10.4274/turkderm.galenos.2019.71224.
Ebrahim AA, Mustafa AI, Abdel-Halim WA, Abo-Ghanema DM. Ischemic Modified Albumin as A Biomarker in Predicting Oxidative Stress in Patients With Acne Vulgaris. Benha Journal of Applied Sciences. 2020;5(8):205-209. DOI: 10.21608/bjas.2020.187209.
Tunçez Akyürek F, Saylam Kurtipek G, Kurku H, et al. Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris. J Cosmet Dermatol. 2020;19(12):3408-3413. DOI:10.1111/jocd.13590. PMID: 32623816.
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