M2 Polarization May Contribute to Formation of Granulomatous Dermatitis in Progression of Myelodysplastic Syndrome to Acute Myeloid Leukemia

Wei-Cheng Fang; Jeng-Shiun Du; Yue-Chiu Su; Li-Wen Chiu; Ting-Ting Yang

doi:10.5826/dpc.1304a241

M2 Polarization May Contribute to Formation of Granulomatous Dermatitis in Progression of Myelodysplastic Syndrome to Acute Myeloid Leukemia

Authors

Wei-Cheng Fang Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
Jeng-Shiun Du Division of Hematology and Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Yue-Chiu Su Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
Li-Wen Chiu Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
Ting-Ting Yang Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

Keywords:

granulomatous dermatitis, myelodysplastic syndrome

References

Vestey JP, Turner M, Biddlestone L, McLaren K, Goulden N, Hunter JA. Disseminated cutaneous granulomatous eruptions associated with myelodysplastic syndrome and acute myeloid leukaemia. Clin Exp Dermatol. 1993;18(6):559-63.

Balin SJ, Wetter DA, Kurtin PJ, Letendre L, Pittelkow MR. Myelodysplastic syndrome presenting as generalized granulomatous dermatitis. Arch Dermatol. 2011;147(3):331-5.

Cornejo KM, Lum CA, Izumi AK. A cutaneous interstitial granulomatous dermatitis-like eruption arising in myelodysplasia with leukemic progression. Am J Dermatopathol. 2013;35(2):e26-9.

Terai S, Ueda-Hayakawa I, Nguyen CTH, Ly NTM, Yamazaki F, Kambe N, et al. Palisaded neutrophilic and granulomatous dermatitis associated with systemic lupus erythematosus: possible involvement of CD163(+) M2 macrophages in two cases, and a review of published works. Lupus. 2018;27(14):2220-7.

Cencini E, Fabbri A, Sicuranza A, Gozzetti A, Bocchia M. The Role of Tumor-Associated Macrophages in Hematologic Malignancies. Cancers (Basel). 2021;13(14).

Zhang G, Yang L, Han Y, Niu H, Yan L, Shao Z, et al. Abnormal Macrophage Polarization in Patients with Myelodysplastic Syndrome. Mediators Inflamm. 2021;2021:9913382.