Retrospective Cohort Study of Hepatic and Hematologic Toxicity in Terbinafine-Treated Onychomycosis Patients With Reduced Kidney Function at an Academic Institution

Kaya L. Curtis; Jose W. Ricardo; Yuqing Qiu; Debra K. Lee; Jamie Hedrick; Henry I. Lipner; Shari R. Lipner

doi:10.5826/dpc.1402a137

Retrospective Cohort Study of Hepatic and Hematologic Toxicity in Terbinafine-Treated Onychomycosis Patients With Reduced Kidney Function at an Academic Institution

Authors

Kaya L. Curtis Weill Cornell Medical College, New York, New York, USA
Jose W. Ricardo Weill Cornell Medicine, Department of Dermatology, New York, New York, USA
Yuqing Qiu Weill Cornell Medicine, Department of Population Health Sciences, New York, New York, USA
Debra K. Lee University of Texas Medical Branch, Galveston, Texas, USA
Jamie Hedrick Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA
Henry I. Lipner Division of Nephrology, Maimonides Medical Center, Brooklyn, New York, USA
Shari R. Lipner Weill Cornell Medicine, Department of Dermatology, New York, New York, USA

Keywords:

terbinafine, onychomycosis, renal, hepatic, hematologic, toxicity, laboratory monitoring, antifungal

References

Lamisil Oral Tablets, Terbinafine HCl Oral Tablets [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2017.

Elewski B, Tavakkol A. Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. Ther Clin Risk Manag. 2005 Dec;1(4):299-306.

Filho AMS, Ventura CG, Criado PR, Del Negro GB, Freitas RS, Luiz OC, Giudice MC, Neto ED, Benard G. Hemodialysis and Kidney Transplantation as Predisposing Conditions to Onychomycosis. Nephron. 2017;137(1):38-46.

Stolmeier DA, Stratman HB, McIntee TJ, Stratman EJ. Utility of Laboratory Test Result Monitoring in Patients Taking Oral Terbinafine or Griseofulvin for Dermatophyte Infections. JAMA Dermatol. 2018 Dec 1;154(12):1409-1416.

Kao WY, Su CW, Huang YS, Chou YC, Chen YC, Chung WH, Hou MC, Lin HC, Lee FY, Wu JC. Risk of oral antifungal agent-induced liver injury in Taiwanese. Br J Clin Pharmacol. 2014 Jan;77(1):180-9.

Moreno-Sabater A, Ouali N, Chasset F, Frances C, Senet P, Faucon C, Hennequin C, Bachmeyer C. Severe onychomycosis management with oral terbinafine in a kidney transplantation setting: Clinical follow-up by image analysis. Mycoses. 2021 Mar;64(3):309-315.

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Published

2024-04-30

Issue

Vol. 14 No. 2 (2024): 2024 Vol 14, No 2 | April

Section

Research Letter

License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Dermatology Practical & Conceptual applies a Creative Commons Attribution License (CCAL) to all works we publish (http://creativecommons.org/licenses/by-nc/4.0/). Authors retain the copyright for their published work.

How to Cite

Retrospective Cohort Study of Hepatic and Hematologic Toxicity in Terbinafine-Treated Onychomycosis Patients With Reduced Kidney Function at an Academic Institution. Dermatol Pract Concept [Internet]. 2024 Apr. 30 [cited 2024 Dec. 5];14(2):e2024137. Available from: https://dpcj.org/index.php/dpc/article/view/4042