Increased Serum Vitamin D and Decreased Serum Cholesterol Are Associated with Development of Squamous Cell Carcinoma in Actinic Keratosis Patients: A Retrospective Machine-Learning Analysis of the All of Us Database

Nilesh Kodali; Rohan Singh; Shari R. Lipner

doi:10.5826/dpc.1404a228

Increased Serum Vitamin D and Decreased Serum Cholesterol Are Associated with Development of Squamous Cell Carcinoma in Actinic Keratosis Patients: A Retrospective Machine-Learning Analysis of the All of Us Database

Authors

Nilesh Kodali Rutgers New Jersey Medical School
Rohan Singh Rutgers New Jersey Medical School
Shari R. Lipner Weill Cornell School of Medicine

Keywords:

Actinic Keratosis, Squamous cell carcinoma, cholesterol, vitamin D

References

Fuchs A, Marmur E. The kinetics of skin cancer: progression of actinic keratosis to squamous cell carcinoma. Dermatol Surg. 2007 Sep;33(9):1099-101. DOI: 10.1111/j.1524-4725.2007.33224.x. PMID: 17760601.

Garcia-Bermudez J, Baudrier L, Bayraktar EC, et al. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. 2019 Mar;567(7746):118-122. DOI: 10.1038/s41586-019-0945-5. Epub 2019 Feb 13. PMID: 30760928; PMCID: PMC6405297.

Mahamat-Saleh Y, Aune D, Schlesinger S. 25-Hydroxyvitamin D status, vitamin D intake, and skin cancer risk: a systematic review and dose-response meta-analysis of prospective studies. Sci Rep. 2020 Aug 4;10(1):13151. DOI: 10.1038/s41598-020-70078-y. PMID: 32753685; PMCID: PMC7403339.

Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer. 2021 Sep 1;21(1):982. DOI: 10.1186/s12885-021-08721-8. PMID: 34470601; PMCID: PMC8411535.

Merriel SW, Carroll R, Hamilton F, Hamilton W. Association between unexplained hypoalbuminaemia and new cancer diagnoses in UK primary care patients. Fam Pract. 2016 Oct;33(5):449-52. DOI: 10.1093/fampra/cmw051. Epub 2016 Jun 25. PMID: 27343860.

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Published

2024-10-30

Issue

Vol. 14 No. 4 (2024): 2024 Vol 14, No 4 | October

Section

Research Letter

License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Dermatology Practical & Conceptual applies a Creative Commons Attribution License (CCAL) to all works we publish (http://creativecommons.org/licenses/by-nc/4.0/). Authors retain the copyright for their published work.

How to Cite

Increased Serum Vitamin D and Decreased Serum Cholesterol Are Associated with Development of Squamous Cell Carcinoma in Actinic Keratosis Patients: A Retrospective Machine-Learning Analysis of the All of Us Database. Dermatol Pract Concept [Internet]. 2024 Oct. 30 [cited 2024 Dec. 6];14(4):2024228. Available from: https://dpcj.org/index.php/dpc/article/view/4309