Systemic Inflammatory Biomarkers in Alopecia Areata: The Role of SII, SIRI, and CRP/Albumin Ratio

Işıl Deniz Oğuz; Sevgi Kulaklı; Burak Akşan

doi:10.5826/dpc.1502a4962

Systemic Inflammatory Biomarkers in Alopecia Areata: The Role of SII, SIRI, and CRP/Albumin Ratio

Authors

Işıl Deniz Oğuz Giresun University School of Medicine, Department of Dermatology, Giresun, Turkey https://orcid.org/0000-0001-8628-6107
Sevgi Kulaklı Giresun University School of Medicine, Department of Dermatology, Giresun, Turkey
Burak Akşan Giresun University School of Medicine, Department of Dermatology, Giresun, Turkey

Abstract

Introduction: Alopecia areata (AA) is an autoimmune disorder with potential roles of both genetic and environmental factors. Although AA is a specific autoimmune disease targeting hair follicles, its frequent association with other autoimmune diseases supports the notion that the autoinflammation is not confined to the hair follicles but is systemic. Systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) and CRP (C-reactive protein) albumin ratio (CAR) are elevated in various diseases and correlate with disease severity.

Objectives: The aim of this study is to determine SII, SIRI and CAR levels in alopecia areata patients, and investigate their correlation with the disease severity.

Methods: Data of 118 AA patients and 122 healthy controls were analyzed. Hemogram, CRP, and albumin values were noted during their clinic visits. CAR, SII and SIRI were calculated in both group.

Results: Although median SIRI and CAR levels were higher in the AA group, the difference was not statistically significant (P>0.05). However median SII was significantly higher in AA group (P<0.001). AA patients were divided two 2 groups according to disease severity as mild disease group (MD) and moderate and severe disease (MSD) group. SII, SIRI and CAR did not differ between two groups.

Conclusions: In AA patients, SIRI and CAR did not show significant differences compared to the normal population, while SII was found to be significantly higher. SII was not associated with disease severity, leading to the conclusion that systemic inflammation can be present even in mild cases of the disease.

Author Biography

Işıl Deniz Oğuz, Giresun University School of Medicine, Department of Dermatology, Giresun, Turkey

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