Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control Study

Melodi Çekiç; Ayşın köktürk; Lülüfer Tamer; Rojda  Tanrıverdi

doi:10.5826/dpc.1503a5015

Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control Study

Authors

Melodi Çekiç acıbadem university department of dermatology istanbul turkey https://orcid.org/0000-0002-1679-9107
Ayşın köktürk Department of Dermatology, Faculty of Medicine, Mersin University, Mersin, Turkey https://orcid.org/0000-0003-3434-9756
Lülüfer Tamer Department of Biochemistry, Faculty of Medicine, Mersin University, Mersin, Turkey https://orcid.org/0000-0002-0997-0260
Rojda Tanrıverdi Department of Biochemistry, Faculty of Medicine, Mersin University, Mersin, Turkey https://orcid.org/0000-0002-7004-790X

Keywords:

Endocan, endoglin, rosacea, inflammation, cardiovascular risk

Abstract

Introduction: Rosacea, a chronic skin disease characterized by facial redness, is believed to involve inflammation and angiogenesis in its pathogenesis. Endocan and endoglin, biomarkers associated with vascular and inflammatory processes, might play roles in rosacea and cardiovascular comorbidities.

Objectives: This study aims to assess serum levels of endocan and endoglin in individuals with rosacea and the function of these biomarkers in indicating comorbidities associated with rosacea.

Methods: A total of 44 patients diagnosed with rosacea and 34 healthy controls were included in this case-control study. The endocan and endoglin levels in serum samples from both groups were measured.

Results: No significant differences in endocan and endoglin levels were observed between the patient and control groups. However, their levels were associated with various clinical features, including symptom and disease severity. A notable association was identified between waist circumference, body mass index and endoglin levels. However, this association was not evident for endocan.

Conclusions: This study suggests endocan and endoglin may play roles in rosacea pathogenesis, with endoglin potentially associated with increased cardiovascular risk.

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