Patient Burden And Impact Of Moderate-to-Severe Atopic Dermatitis In the Spanish Healthcare System: The APOLO Cross-Sectional Study

Patient Burden And Impact Of Moderate-to-Severe Atopic Dermatitis In the Spanish Healthcare System: The APOLO Cross-Sectional Study

Authors

  • Pablo De La Cueva Dobao Hospital Universitario Infanta Leonor - Gran Vía del Este, 80, 28031 Madrid
  • Laia Curto Barredo Hospital del Mar - Pg. Marítim de la Barceloneta, 25, 29, Ciutat Vella, 08003 Barcelona
  • Juan Francisco Silvestre Salvador Hospital General Universitario Dr. Balmis - C/Pintor Baeza, 11, 03010 Alicante
  • Esther Serra Baldrich Hospital de la Santa Creu i Sant Pau - C/Sant Quintí, 89, Horta-Guinardó, 08025 Barcelona
  • Pedro Herranz Pinto Dermatology department, La Paz University Hospital; Autonomous University of Madrid - P.º de la Castellana, 261, Fuencarral-El Pardo, 28046 Madrid
  • Natalia Hernández Cano Dermatology department, La Paz University Hospital; Autonomous University of Madrid - P.º de la Castellana, 261, Fuencarral-El Pardo, 28046 Madrid
  • Francisco Javier Ortiz De Frutos Hospital Universitario 12 de Octubre - Av. De Córdoba s/n, Usera, 28041 Madrid
  • Gastón Roustan Gullón Hospital Universitario Puerta de Hierro - C/Joaquín Rodrigo, 1, 28222 Majadahonda (Madrid)
  • Rosa María Izu Belloso Hospital Universitario de Basurto - Montevideo Etorb., 18, Basurtu-Zorrotza, 48013 Bilbo, (Bizkaia)
  • Irene Arévalo Ortega Hospital Universitario de Basurto - Montevideo Etorb., 18, Basurtu-Zorrotza, 48013 Bilbo, (Bizkaia)
  • Alicia González Quesada Hospital Universitario de Gran Canaria Dr. Negrín - C. Pl. Barranco de la Ballena, s/n, 35010 Las Palmas de Gran Canaria
  • Manuel Galán Gutiérrez Hospital Universitario Reina Sofía - Av. Menéndez Pidal, s/n, Poniente Sur, 14004 Córdoba
  • Yolanda Gilaberte Calzada Hospital Universitario Miguel Servet - P.º de Isabel la Católica, 1-3, 50009 Zaragoza
  • Daniel Arumi Torredemer PFIZER S.L.U. - Avda. Europa, 20, B, 28108 Alcobendas (Madrid)
  • Noelia Llevat Felius PFIZER S.L.U. - Avda. Europa, 20, B, 28108 Alcobendas (Madrid)
  • Irene Hernández Martín PFIZER S.L.U. - Avda. Europa, 20, B, 28108 Alcobendas (Madrid)
  • Francisco José Rebollo Laserna PFIZER S.L.U. - Avda. Europa, 20, B, 28108 Alcobendas (Madrid)

Keywords:

Atopic dermatitis, pruritus, burden of disease, quality of life, healthcare resources

Abstract

Introduction: Atopic dermatitis (AD) is an inflammatory chronic condition associated with a significant physical, psychological, and economic burden.

Objective: This study aims to determine the multidimensional impact of atopic dermatitis (AD) on patients and the Spanish healthcare system.

Methods: The APOLO is a multicenter, descriptive, cross-sectional study conducted at 12 Spanish sites, in which participants completed a series of scales and questionnaires.

Results: Of 62 patients included (54.8% men; mean [standard deviation] age: 33.1 [12.8] years), 61.3% and 38.7% had moderate and severe AD, respectively (validated Investigator Global Assessment scale for AD). AD affected a mean of 43.3% (22.1) of the body surface, and patients reported a median (interquartile range) of 4.0 (2.0-10.0) flares in the previous year. The mean Patient-Oriented Eczema Measure (POEM) score was 19.8 (6.4), indicating a severe eczema stage. Additionally, 57.1% of patients experienced pain daily due to scratching or skin inflammation. The Dermatology Life Quality Index (DLQI) showed a strong AD impact on patients’ quality of life (mean DLQI=14.3 [7.6]), positively correlated with severity, pruritus, and pain. AD also affected patients’ work/academic activities and sleep. The disease was mostly treated with topical corticosteroids (81.5%) and emollients (75.9%). In the prior year, no patient required hospitalization; and 25% of patients resorted to alternative therapies/unlicensed products.

Conclusions: AD profoundly impacts patients’ quality of life and entails high economic costs. This study emphasizes the need for more effective treatment strategies and an improved understanding of the AD burden to utilize public healthcare resources more efficiently.

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Published

2025-07-31

How to Cite

1.
De La Cueva Dobao P, Curto Barredo L, Silvestre Salvador JF, et al. Patient Burden And Impact Of Moderate-to-Severe Atopic Dermatitis In the Spanish Healthcare System: The APOLO Cross-Sectional Study. Dermatol Pract Concept. 2025;15(3):5538. doi:10.5826/dpc.1503a5538

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