Patient Burden And Impact Of Moderate-to-Severe Atopic Dermatitis In the Spanish Healthcare System: The APOLO Cross-Sectional Study
Keywords:
Atopic dermatitis, pruritus, burden of disease, quality of life, healthcare resourcesAbstract
Introduction: Atopic dermatitis (AD) is an inflammatory chronic condition associated with a significant physical, psychological, and economic burden.
Objective: This study aims to determine the multidimensional impact of atopic dermatitis (AD) on patients and the Spanish healthcare system.
Methods: The APOLO is a multicenter, descriptive, cross-sectional study conducted at 12 Spanish sites, in which participants completed a series of scales and questionnaires.
Results: Of 62 patients included (54.8% men; mean [standard deviation] age: 33.1 [12.8] years), 61.3% and 38.7% had moderate and severe AD, respectively (validated Investigator Global Assessment scale for AD). AD affected a mean of 43.3% (22.1) of the body surface, and patients reported a median (interquartile range) of 4.0 (2.0-10.0) flares in the previous year. The mean Patient-Oriented Eczema Measure (POEM) score was 19.8 (6.4), indicating a severe eczema stage. Additionally, 57.1% of patients experienced pain daily due to scratching or skin inflammation. The Dermatology Life Quality Index (DLQI) showed a strong AD impact on patients’ quality of life (mean DLQI=14.3 [7.6]), positively correlated with severity, pruritus, and pain. AD also affected patients’ work/academic activities and sleep. The disease was mostly treated with topical corticosteroids (81.5%) and emollients (75.9%). In the prior year, no patient required hospitalization; and 25% of patients resorted to alternative therapies/unlicensed products.
Conclusions: AD profoundly impacts patients’ quality of life and entails high economic costs. This study emphasizes the need for more effective treatment strategies and an improved understanding of the AD burden to utilize public healthcare resources more efficiently.
References
Barbarot S, Auziere S, Gadkari A, et al. Epidemiology of atopic dermatitis in adults: Results from an international survey. Allergy. Jun 2018;73(6):1284-1293. doi:10.1111/all.13401
Silverberg JI, Barbarot S, Gadkari A, et al. Atopic dermatitis in the pediatric population: A cross-sectional, international epidemiologic study. Ann Allergy Asthma Immunol. Apr 2021;126(4):417-428 e2. doi:10.1016/j.anai.2020.12.020
Laughter MR, Maymone MBC, Mashayekhi S, et al. The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990-2017. Br J Dermatol. Feb 2021;184(2):304-309. doi:10.1111/bjd.19580
Escarrer J, Guerra Pérez M. Dermatitis atópica. Protoc diagn ter pediatr. 2019;2:161-75.
Silverberg JI, Gelfand JM, Margolis DJ, et al. Patient burden and quality of life in atopic dermatitis in US adults: A population-based cross-sectional study. Ann Allergy Asthma Immunol. Sep 2018;121(3):340-347. doi:10.1016/j.anai.2018.07.006
Carroll CL, Balkrishnan R, Feldman SR, Fleischer AB, Jr., Manuel JC. The burden of atopic dermatitis: impact on the patient, family, and society. Pediatr Dermatol. May-Jun 2005;22(3):192-9. doi:10.1111/j.1525-1470.2005.22303.x
Drucker AM, Wang AR, Li WQ, Sevetson E, Block JK, Qureshi AA. The Burden of Atopic Dermatitis: Summary of a Report for the National Eczema Association. J Invest Dermatol. Jan 2017;137(1):26-30. doi:10.1016/j.jid.2016.07.012
Xu X, van Galen LS, Koh MJA, et al. Factors influencing quality of life in children with atopic dermatitis and their caregivers: a cross-sectional study. Sci Rep. Nov 5 2019;9(1):15990. doi:10.1038/s41598-019-51129-5
Simpson E, Bissonnette R, Eichenfield LF, et al. The Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD): The development and reliability testing of a novel clinical outcome measurement instrument for the severity of atopic dermatitis. J Am Acad Dermatol. Sep 2020;83(3):839-846. doi:10.1016/j.jaad.2020.04.104
Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. Clin Exp Dermatol. May 1994;19(3):210-6. doi:10.1111/j.1365-2230.1994.tb01167.x
EuroQol G. EuroQol--a new facility for the measurement of health-related quality of life. Health Policy. Dec 1990;16(3):199-208. doi:10.1016/0168-8510(90)90421-9
Lewis-Jones MS, Finlay AY. The Children's Dermatology Life Quality Index (CDLQI): initial validation and practical use. Br J Dermatol. Jun 1995;132(6):942-9. doi:10.1111/j.1365-2133.1995.tb16953.x
Reilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics. Nov 1993;4(5):353-65. doi:10.2165/00019053-199304050-00006
Lawson V, Lewis-Jones MS, Finlay AY, Reid P, Owens RG. The family impact of childhood atopic dermatitis: the Dermatitis Family Impact Questionnaire. Br J Dermatol. Jan 1998;138(1):107-13. doi:10.1046/j.1365-2133.1998.02034.x
Charman CR, Venn AJ, Williams HC. The patient-oriented eczema measure: development and initial validation of a new tool for measuring atopic eczema severity from the patients' perspective. Arch Dermatol. Dec 2004;140(12):1513-9. doi:10.1001/archderm.140.12.1513
Yosipovitch G, Reaney M, Mastey V, et al. Peak Pruritus Numerical Rating Scale: psychometric validation and responder definition for assessing itch in moderate-to-severe atopic dermatitis. Br J Dermatol. Oct 2019;181(4):761-769. doi:10.1111/bjd.17744
Hanifin JM, Thurston M, Omoto M, Cherill R, Tofte SJ, Graeber M. The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. EASI Evaluator Group. Exp Dermatol. Feb 2001;10(1):11-8. doi:10.1034/j.1600-0625.2001.100102.x
Murray CJ, Lopez AD. Measuring the global burden of disease. N Engl J Med. Aug 1 2013;369(5):448-57. doi:10.1056/NEJMra1201534
Beretzky Z, Koszoru K, Rencz F, et al. Societal costs and health related quality of life in adult atopic dermatitis. BMC Health Serv Res. Aug 14 2023;23(1):859. doi:10.1186/s12913-023-09840-7
Eyerich K, Gooderham MJ, Silvestre JF, et al. Real-world clinical, psychosocial and economic burden of atopic dermatitis: Results from a multicountry study. J Eur Acad Dermatol Venereol. Feb 2024;38(2):340-353. doi:10.1111/jdv.19500
Sanchez-Perez J, Dauden-Tello E, Mora AM, Lara Surinyac N. Impact of atopic dermatitis on health-related quality of life in Spanish children and adults: the PSEDA study. Actas Dermosifiliogr. Jan 2013;104(1):44-52. doi:10.1016/j.ad.2012.03.008
Fasseeh AN, Elezbawy B, Korra N, et al. Burden of Atopic Dermatitis in Adults and Adolescents: a Systematic Literature Review. Dermatol Ther (Heidelb). Dec 2022;12(12):2653-2668. doi:10.1007/s13555-022-00819-6
Kleyn CE, Barbarot S, Reed C, et al. Burden of Moderate to Severe Atopic Dermatitis in Adults from France, Italy, and the UK: Patient-Reported Outcomes and Treatment Patterns. Dermatol Ther (Heidelb). Aug 2022;12(8):1947-1965. doi:10.1007/s13555-022-00777-z
Ohya Y, Saeki H, Nawata H, et al. The disease burden of pediatric patients with atopic dermatitis in Japan. Pediatr Dermatol. Sep-Oct 2023;40(5):851-856. doi:10.1111/pde.15399
Bender BG, Leung DY. Sleep disorders in patients with asthma, atopic dermatitis, and allergic rhinitis. J Allergy Clin Immunol. Dec 2005;116(6):1200-1. doi:10.1016/j.jaci.2005.09.041
Yu SH, Attarian H, Zee P, Silverberg JI. Burden of Sleep and Fatigue in US Adults With Atopic Dermatitis. Dermatitis. Mar-Apr 2016;27(2):50-8. doi:10.1097/DER.0000000000000161
Civelek E, Sahiner UM, Yuksel H, et al. Prevalence, burden, and risk factors of atopic eczema in schoolchildren aged 10-11 years: a national multicenter study. J Investig Allergol Clin Immunol. 2011;21(4):270-7.
Augustin M, Misery L, von Kobyletzki L, Armario-Hita JC, Mealing S, Redding M. Unveiling the true costs and societal impacts of moderate-to-severe atopic dermatitis in Europe. J Eur Acad Dermatol Venereol. Jul 2022;36 Suppl 7:3-16. doi:10.1111/jdv.18168
Mohr N, Naatz M, Zeervi L, et al. Cost-of-illness of atopic dermatitis in Germany: data from dermatology routine care. J Eur Acad Dermatol Venereol. Jun 2021;35(6):1346-1356. doi:10.1111/jdv.17203
Sicras-Mainar A, Navarro-Artieda R, Carrascosa Carrillo JM. Economic Impact of Atopic Dermatitis in Adults: A Population-Based Study (IDEA Study). Actas Dermosifiliogr (Engl Ed). Jan-Feb 2018;109(1):35-46. Impacto economico de la dermatitis atopica en adultos: estudio de base poblacional (estudio IDEA). doi:10.1016/j.ad.2017.09.003
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Pablo De La Cueva Dobao, Laia Curto Barredo, Juan Francisco Silvestre Salvador, Esther Serra Baldrich, Pedro Herranz Pinto, Natalia Hernández Cano, Francisco Javier Ortiz De Frutos, Gastón Roustan Gullón, Rosa María Izu Belloso, Irene Arévalo Ortega, Alicia González Quesada, Manuel Galán Gutiérrez, Yolanda Gilaberte Calzada, Daniel Arumi Torredemer, Noelia Llevat Felius, Irene Hernández Martín, Francisco José Rebollo Laserna

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Dermatology Practical & Conceptual applies a Creative Commons Attribution License (CCAL) to all works we publish (http://creativecommons.org/licenses/by-nc/4.0/). Authors retain the copyright for their published work.