Line-Field Confocal Optical Coherence Tomography in Merkel Cell Carcinoma and Histopathological Correlation

Line-Field Confocal Optical Coherence Tomography in Merkel Cell Carcinoma and Histopathological Correlation

Authors

  • Maria Elisabetta Greco Unit of Dermatology, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, “Sapienza” University of Rome, 00185 Rome, Italy
  • Antonio Di Guardo Unit of Dermatology, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, “Sapienza” University of Rome, 00185 Rome, Italy https://orcid.org/0000-0002-0117-346X
  • Andrea Ascione Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 - Rome
  • Giuseppe Soda Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 - Rome
  • Giovanni Pellacani Unit of Dermatology, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, “Sapienza” University of Rome, 00185 Rome, Italy
  • Flavia Persechino Unit of Dermatology, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, “Sapienza” University of Rome, 00185 Rome, Italy

Keywords:

Merkel cell carcinoma, LC-OCT, non-invasive imaging, Skin Cancer

References

Gass JK, Chan SK, Rytina E, Greenberg DC, Burrows NP. Multiple primary malignancies in patients with Merkel cell carcinoma. J Eur Acad Dermatol Venereol. 2010;24(5):601-603. DOI:10.1111/j.1468-3083.2009.03458.x. PMID: 19900177.

Suppa M, Palmisano G, Tognetti L, et al. Line-field confocal optical coherence tomography in melanocytic and non-melanocytic skin tumors. Ital J Dermatol Venerol. 2023 Jun;158(3):180-189. DOI: 10.23736/s2784-8671.23.07639-9 PMID: 37278496.

Badiu IM, Korecka K, Orzan AO, et al.A Review of Non-Invasive Skin Imaging in Merkel Cell Carcinoma: Diagnostic Utility and Clinical Implications. Cancers (Basel). 2024 Oct 24;16(21):3586. DOI: 10.3390/cancers16213586. PMID: 39518026.

Longo C, Benati E, Borsari S, et al. Merkel cell carcinoma: morphologic aspects on reflectance confocal microscopy. J Eur Acad Dermatol Venereol. 2017 Nov;31(11):e480-e481. DOI: 10.1111/jdv.14333. PMID: 28502121.

Perez-Anker J, Puig S, Alos L, et al. Morphological evaluation of melanocytic lesions with three-dimensional line-field confocal optical coherence tomography: correlation with histopathology and reflectance confocal microscopy. A pilot study. Clin Exp Dermatol. 2022;47(12):2222-2233. DOI:10.1111/ced.15383. PMID: 35988042.

Zwijnenburg EM, Lubeek SFK, Werner JEM, et al. Merkel Cell Carcinoma: New Trends. Cancers. 2021; 13(7):1614. DOI: 10.3390/cancers13071614. PMID: 33807446.

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Published

2025-10-31

Issue

Vol. 15 No. 4 (2025): 2025 Vol 15, No 4 | October

Section

Research Letter

License

Copyright (c) 2025 Maria Elisabetta Greco, Antonio Di Guardo, Andrea Ascione, Giuseppe Soda, Giovanni Pellacani, Flavia Persechino

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Dermatology Practical & Conceptual applies a Creative Commons Attribution License (CCAL) to all works we publish (http://creativecommons.org/licenses/by-nc/4.0/). Authors retain the copyright for their published work.

How to Cite

1.
Greco ME, Di Guardo A, Ascione A, Soda G, Pellacani G, Persechino F. Line-Field Confocal Optical Coherence Tomography in Merkel Cell Carcinoma and Histopathological Correlation. Dermatol Pract Concept. 2025;15(4):5647. doi:10.5826/dpc.1504a5647

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