Non-Invasive Imaging Markers for Acne Treatment Response Monitoring: A Pilot Study During Use of a Topical Product Containing Silybum Marianum Fruit Extract

Non-Invasive Imaging Markers for Acne Treatment Response Monitoring: A Pilot Study During Use of a Topical Product Containing Silybum Marianum Fruit Extract

Authors

  • Marco Ardigò Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy https://orcid.org/0000-0002-5772-4937
  • Gautier Doat Laboratoires Dermatologiques Avène, Pierre Fabre Dermo-Cosmétique, Lavaur, France
  • Aline Stennevin Laboratoires Dermatologiques Avène, Pierre Fabre Dermo-Cosmétique, Lavaur, France

Keywords:

acne vulgaris, treatment monitoring, reflectance confocal microscopy, optical coherence tomography

References

Alma A, Sticchi A, Chello C, et al. Dermoscopy, Reflectance Confocal Microscopy and Optical Coherence Tomography Features of Acne: A Systematic Review. J Clin Med. 2022;11(7):1783.DOI 10.3390/jcm11071783.

Manfredini M, Bettoli V, Sacripanti G, et al. The evolution of healthy skin to acne lesions: a longitudinal, in vivo evaluation with reflectance confocal microscopy and optical coherence tomography. J Eur Acad Dermatol Venereol. 2019 Sep;33(9):1768-74.DOI 10.1111/jdv.15641

Manfredini M, Mazzaglia G, Ciardo S, et al. Acne: in vivo morphologic study of lesions and surrounding skin by means of reflectance confocal microscopy. J Eur Acad Dermatol Venereol. 2015 May;29(5):933-9.DOI 10.1111/jdv.12730

Fuchs CSK, Andersen AJB, Ardigo M, et al. Acne vulgaris severity graded by in vivo reflectance confocal microscopy and optical coherence tomography. Lasers Surg Med. 2019 Jan;51(1):104-13.DOI 10.1002/lsm.23008

Manfredini M, Greco M, Farnetani F, et al. Acne: morphologic and vascular study of lesions and surrounding skin by means of optical coherence tomography. J Eur Acad Dermatol Venereol. 2017 Sep;31(9):1541-46.DOI 10.1111/jdv.14369

Manfredini M, Sticchi A, Lippolis N, et al. Characterization of Acne-Prone Skin with Reflectance Confocal Microscopy and Optical Coherence Tomography and Modifications Induced by Topical Treatment and Probiotic Supplementation. J Clin Med. 2023 Jul 20;12(14).DOI 10.3390/jcm12144787

Saurat J-H, Reygagne P, Josse G, et al. Long-Term Use of Silybum marianum fruit extract Contributes to Homeostasis in Acne-Prone Skin—A 12-Month Follow-Up International “Real Life” Cohort Study. J Pers Med. 2022;13(1):96.DOI 10.3390/jpm13010096

Crocco EI, Alves RO, Carvalho GS, et al. Reflectance confocal microscopy and clinical evaluation of a product containing Silybum marianum fruit extract in monotherapy for acne vulgaris treatment: A prospective study. JEADV Clinical Practice. 2024;3(4):1085-94

Saurat J-H. Strategic Targets in Acne: The Comedone Switch in Question. Dermatology. 2015;231(2):105-11.DOI 10.1159/000382031

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Published

2025-12-29

Issue

Section

Research Letter

How to Cite

1.
Ardigò M, Doat G, Stennevin A. Non-Invasive Imaging Markers for Acne Treatment Response Monitoring: A Pilot Study During Use of a Topical Product Containing Silybum Marianum Fruit Extract. Dermatol Pract Concept. 2025;16:6959. doi:10.5826/dpc.1601a6959

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