CORONATE: A Novel Questionnaire to Assess the Long-Term Impact of Psoriasis on Patients’ Lives

Stefano  Piaserico; Francesca  Sampogna; Martina  Accorinti; Paolo  Amerio; Claudio  Bonifati; Alexandra M.G.  Brunasso; Martina  Burlando; Christian  Ciolfi; Andrea  Conti; Sara Di Fino; Maria  Esposito; Gennaro Marco  Falco; Maria Concetta  Fargnoli; Caterina  Foti; Paolo  Gisondi; Dario Graceffa; Claudio Guarneri; Marika  Iarrera; Francesco  Loconsole; Anna  Levi; Alessia  Lozito; Daria Nucciarelli; Giulia  Nunziati; Anna Maria  Offidani; Aurora  Parodi; Pietro  Perini; Lucia  Peterle; Francesca Prignano; Simone  Ribero; Paolo  Romita; Francesca  Satolli; Marina Venturini; Barbara  Zucchi; Clara De Simone

doi:10.5826/dpc.160a7073

CORONATE: A Novel Questionnaire to Assess the Long-Term Impact of Psoriasis on Patients’ Lives

Authors

Stefano Piaserico Dermatology Unit, Department of Medicine, DIMED, Università di Padova, Italy
Francesca Sampogna Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy
Martina Accorinti Department of Medical Sciences, Dermatology Clinic, University of Turin, Turin, Italy
Paolo Amerio Department of Medicine and Aging Science, University of Chieti-Pescara, Chieti, Italy
Claudio Bonifati San Gallicano Dermatological Institute, IRCCS, Rome, Italy
Alexandra M.G. Brunasso Department of Internal Medicine-Dermatology, Villa Scassi Hospital-ASL3, Genoa, Italy
Martina Burlando Clinica Dermatologica – DISSAL, Ospedale Policlinico San Martino-IRCCS Università di Genova, Italy
Christian Ciolfi Dermatology Unit, Department of Medicine, DIMED, Università di Padova, Italy
Andrea Conti Department of Surgery, Dermatology Unit, Infermi Hospital, Rimini, AUSL Romagna, Rimini, Italy
Sara Di Fino AbbVie srl, Rome Italy
Maria Esposito Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
Gennaro Marco Falco Section of Dermatology, Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy; Dermatology Unit, Policlinico A. Gemelli, IRCCS, Rome, Italy
Maria Concetta Fargnoli Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
Caterina Foti Section of Dermatology, Department of Precision and Regenerative Medicine and Jonian Area, University of Bari, Bari, Italy
Paolo Gisondi Section of Dermatology and Venereology Department of Medicine, University of Verona, Italy
Dario Graceffa Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Dermatology, University of Messina, Messina, Italy
Claudio Guarneri Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Dermatology, University of Messina, Messina, Italy
Marika Iarrera Dermatologic Unit, Infermi Hospital Rimini, AUSL Romagna, Italy
Francesco Loconsole Azienda Ospedaliera Universitaria Policlinico Consorziale Bari, Italy
Anna Levi AbbVie srl, Rome Italy
Alessia Lozito Section of Dermatology and Venereology Department of Medicine, University of Verona, Italy
Daria Nucciarelli AbbVie srl, Rome Italy
Giulia Nunziati Department of Health Sciences, Section of dermatology, University of Florence, Italy
Anna Maria Offidani Department of Clinical and Molecular Sciences, Dermatology Unit Polytechnic Marche, Università, Ancona, Italy
Aurora Parodi Clinica Dermatologica – DISSAL, Ospedale Policlinico San Martino-IRCCS Università di Genova, Italy
Pietro Perini UOC Dermatology, Department of Medicine and Surgery, University of Parma, Parma, Italy
Lucia Peterle Section of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
Francesca Prignano Department of Health Sciences, Section of dermatology, University of Florence, Italy
Simone Ribero Department of Medical Sciences, Dermatology Clinic, University of Turin, Turin, Italy
Paolo Romita Section of Dermatology, Department of Precision and Regenerative Medicine and Jonian Area, University of Bari, Bari, Italy
Francesca Satolli UOC Dermatology, Department of Medicine and Surgery, University of Parma, Parma, Italy
Marina Venturini Department of Clinical and Experimental Sciences, Dermatology Clinic, ASST-Spedali Civili Hospital and University of Brescia, Brescia, Italy
Barbara Zucchi AbbVie srl, Rome Italy
Clara De Simone Section of Dermatology, Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy; Dermatology Unit, Policlinico A. Gemelli, IRCCS, Rome, Italy

Keywords:

Psoriasis, cumulative life course impairment (CLCI), quality of life, psychometric validation, patient-reported outcomes

Abstract

Introduction: Psoriasis has a profound impact on patients’ quality of life, affecting their emotional well-being, social interactions, and career choices. However, current assessment tools fail to capture the long-term burden of psoriasis.

Objective: The aim of this study was to develop the CORONATE questionnaire, designed to assess the lifelong impact of moderate-to-severe psoriasis on patients' lives.

Methods: A multicenter cross-sectional study was conducted in 15 Italian dermatology centers. This study included 300 patients (age ≥30 years) diagnosed with moderate-to-severe psoriasis (PASI ≥10 or PASI <10 with involvement of sensitive areas). The CORONATE questionnaire, initially consisting of 25 items, was refined through factor analysis. Exploratory and confirmatory factor analyses were performed.

Results: The final questionnaire included 18 items grouped into two dimensions: "Work Issues" (5 items) and "Psychosocial Life" (13 items). Factor analysis confirmed strong internal consistency (Cronbach’s alpha: Work Issues = 0.81; Psychosocial Life = 0.91). The model showed excellent fit indices (χ² (153) = 6956.471, P<0.001; Comparative Fit Index = 0.998; Tucker-Lewis Index = 0.998; Standardized Root Mean Square Residual = 0.053).

Conclusion: The CORONATE questionnaire is a reliable tool for assessing the cumulative burden of psoriasis. Its implementation in clinical practice may improve personalized patient care.

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