Histiocytoid Sweet’s syndrome in a patient with myelodysplastic syndrome: report and review of the literature

Michael M. Shalaby; Ryan R. Riahl; Les B. Rosen; Erik J. Soine

doi:10.5826/dpc.0601a04

Histiocytoid Sweet’s syndrome in a patient with myelodysplastic syndrome: report and review of the literature

Authors

Michael M. Shalaby Medical School, Louisiana State University Health Sciences Center, New Orleans, LA, USA
Ryan R. Riahl Department of Dermatology, Louisiana State University, New Orleans, LA, USA
Les B. Rosen Dermpath Diagnostics, Pompano Beach, FL, USA
Erik J. Soine Soine Dermatology & Aesthetics, New Orleans, LA, USA

Keywords:

histiocytoid Sweet's, myelodysplasia, myelodysplastic, sweet, sweet's, syndrome

Abstract

The neutrophilic dermatoses are a group of disorders characterized by skin lesions for which histological examination reveals intense epidermal and/or dermal inflammatory infiltrates composed primarily of neutrophils without evidence of infection. The myelodysplastic syndromes consist of a heterogeneous group of malignant hematopoietic stem cell disorders characterized by dysplastic and inadequate blood cell production with a variable risk of transformation to acute leukemia. Rarely, histiocytoid Sweet’s syndrome occurring in patients with myelodysplastic syndrome has been described. We present a case of a 66-year-old woman with a history of myelodysplastic syndrome who developed histiocytoid Sweet’s syndrome. We also review the literature and characterize patients with myelodysplastic syndrome who have developed histiocytoid Sweet’s syndrome.