Share:
Original Article

Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Field of Dermatology and Cosmetics

Author Affiliation(s)

Abstract

Introduction: Slowing the aging process by use of collagen supplements has become a driving force in the field of dermatology and cosmetics. Generally, oral and topical collagen are used in anti-aging products, as reported in the literature.


Objectives: The overarching goal of this research is to collate the consequences of oral collagen with those of topical collagen in reducing or delaying the aging process.


Methods: We executed an electronic search in Google Scholar and PubMed. We considered a study eligible if it was original research, published in English between 2010 and 2020, and if it provided information on the topic of collagen and aging. We retrieved 12 full-text articles, and these were assessed by reviewers independently.


Results: All human studies included in the review were randomized controlled trials mainly conducted in high- to middle-income countries which highlighted that both oral and topical collagen supplements help to delay the aging process, with no differences arising between the two types of collagen. The evidence from the reviewed studies suggested that both collagen supplements improve skin moisture, elasticity, and hydration when orally administered. Additionally, collagen reduces the wrinkling and roughness of the skin, and existing studies have not found any side effects of its oral supplements.


Conclusions: Both oral and topical collagen can contribute to reducing or delaying skin aging. Future epidemiological studies with large sample sizes and thorough follow-up measures would be required to comprehensively understand the potential effects of these two types of collagen on the aging process.

Keywords : aging, oral collagen, topical collagen, collagen supplements, wrinkling

References

1. Tobin DJ. Introduction to skin aging. J Tissue Viability. 2017;26(1):37–46. DOI: 10.1016/j.jtv.2016.03.002. PMID: 27020864. 2. Barbosa MC, Grosso RA, Fader CM. Hallmarks of aging: an autophagic perspective. Front Endocrinol (Lausanne). 2019;9:790. DOI: 10.3389/fendo.2018.00790. PMID: 30687233. PMCID: PMC6333684. 3. Cannarozzo G, Fazia G, Bennardo L, et al. A New 675 nm Laser Device in the Treatment of Facial Aging: A Prospective Observational Study. Photobiomodul Photomed Laser Surg. 2021;39(2):118-122. DOI: 10.1089/photob.2020.4908. PMID: 33449869. 4. Nistico SP, Silvestri M, Zingoni T, Tamburi F, Bennardo L, Cannarozzo G. Combination of Fractional CO2 Laser and Rhodamine-Intense Pulsed Light in Facial Rejuvenation: A Randomized Controlled Trial. Photobiomodul Photomed Laser Surg. 2021;39(2):113-117. DOI: 10.1089/photob.2020.4876. PMID: 33449867. 5. Varani J, Dame MK, Rittie L, et al. Decreased collagen production in chronologically aged skin: Roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol. 2006;168(6):1861–1868. DOI: 10.2353/ajpath.2006.051302. PMID: 16723701. PMCID: PMC1606623. 6. Lee DH, Oh J-H, Chung JH. Glycosaminoglycan and proteoglycan in skin aging. Journal of Dermatological Science. 2016;83(3):174–181. DOI: 10.1016/j.jdermsci.2016.05.016. PMID: 27378089. 7. Reilly DM, Lozano J. Skin collagen through the lifestages: importance for skin health and beauty. Plast Aesthet Res. 2021;8:2. DOI: 10.20517/2347-9264.2020.153 8. De Melo F, Nicolau P, Piovano L, et al. Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé®). Clin Cosmet Investig Dermatol. 2017;10:431-440. DOI: 10.2147/CCID.S145195. PMID: 29184426. PMCID: PMC5685142. 9. Li P, Wu G. Roles of dietary glycine, proline, and hydroxyproline in collagen synthesis and animal growth. Amino Acids. 2018;50(1):29–38. DOI: 10.1007/s00726-017-2490-6. PMID: 28929384. 10. Felician FF, Xia C, Qi W, Xu H. Collagen from marine biological sources and medical applications. Chem Biodivers. 2018;15(5):e1700557. DOI: 10.1002/cbdv.201700557. PMID: 29521032. 11. Cho BA, Yoo S-K, Seo J-S. Signatures of photo-aging and intrinsic aging in skin were revealed by transcriptome network analysis. Aging (Albany NY). 2018;10(7):1609-1626. DOI: 10.18632/aging.101496. PMID: 30021930. PMCID: PMC6075446. 12. McCabe MC, Hill RC, Calderone K, et al. Alterations in extracellular matrix composition during aging and photoaging of the skin. Matrix Biol Plus. 2020;8:100041. DOI: 10.1016/j.mbplus.2020.100041. PMID: 33543036. PMCID: PMC7852213. 13. Zhang L, Zhang S, Song H, Li B. Ingestion of collagen hydrolysates alleviates skin chronological aging in an aged mouse model by increasing collagen synthesis. Food Funct. 2020;11(6):5573-5580. DOI: 10.1039/d0fo00153h. PMID: 32520042. 14. Exposito JY, Valcourt U, Cluzel C, Lethias C. The fibrillar collagen family. Int J Mol Sci. 2010;11(2):407-426. DOI: 10.3390/ijms11020407. PMID: 20386646; PMCID: PMC2852846. 15. Zhang Z, Wang J, Ding Y, Dai X, Li Y. Oral administration of marine collagen peptides from Chum Salmon skin enhances cutaneous wound healing and angiogenesis in rats. J Sci Food Agric. 2011;91(12):2173-2179. DOI: 10.1002/jsfa.4435. PMID: 21560132.. 16. Sionkowska A, Skrzyński S, Śmiechowski K, Kołodziejczak A. The review of versatile application of collagen. Polymers for Advanced Technologies. 2017;28(1):4–9. DOI: 10.1002/pat.3842. 17. Choi SY, Ko EJ, Lee YH, et al. Effects of collagen tripeptide supplement on skin properties: A prospective, randomized, controlled study. J Cosmet Laser Ther. 2014;16(3):132-137. DOI: 10.3109/14764172.2013.854119. PMID: 24131075. 18. Addor FASA, Vieira JC, Melo CSA. Improvement of dermal parameters in aged skin after oral use of a nutrient supplement. Clin Cosmet Investig Dermatol. 2018;11:195-201. DOI: 10.2147/CCID.S150269. PMID: 29750046. PMCID: PMC5933363. 19. Genovese L, Corbo A, Sibilla S. An insight into the changes in skin texture and properties following dietary intervention with a nutricosmeceutical containing a blend of collagen bioactive peptides and antioxidants. Skin Pharmacol Physiol. 2017;30(3):146-158. DOI: 10.1159/000464470. PMID: 28528342. 20. Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: A double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. DOI: 10.1159/000351376. PMID: 23949208. 21. Kim D-U, Chung H-C, Choi J, Sakai Y, Lee B-Y. Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity, and wrinkling in human skin: A randomized, double-blind, placebo-controlled study. Nutrients. 2018;10(7):826. DOI: 10.3390/nu10070826. PMID: 29949889. PMCID: PMC6073484. 22. Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo‐controlled clinical study. J Sci Food Agric. 2016;96(12):4077-4081. DOI: 10.1002/jsfa.7606. PMID: 26840887. 23. Wang Z, Wang Q, Wang L, et al. Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice. J Sci Food Agric. 2017;97(9):2721-2726. DOI: 10.1002/jsfa.8098. PMID: 27747904. 24. Le Vu P, Takatori R, Iwamoto T, et al. Effects of food-derived collagen peptides on the expression of keratin and keratin-associated protein genes in the Mouse Skin. Skin Pharmacol Physiol. 2015;28(5):227-235. DOI: 10.1159/000369830. PMID: 25721900. 25. Oba C, Ito K, Ichikawa S, et al. Effect of orally administered collagen hydrolysate on gene expression profiles in mouse skin: A DNA microarray analysis. Physiol Genomics. 2015;47(8):355-363. DOI: 10.1152/physiolgenomics.00009.2015. PMID: 26058835. 26. Shimizu J, Asami N, Kataoka A, et al. Oral collagen-derived dipeptides, prolyl-hydroxyproline and hydroxyprolyl-glycine, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin. Biochem Biophys Res Commun. 2015;456(2):626-630. DOI: 10.1016/j.bbrc.2014.12.006. PMID: 25498544. 27. Sanz MT, Campos C, Milani M, et al. Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs. J Cosmet Dermatol. 2016;15(1):24-30. DOI: 10.1111/jocd.12173. PMID: 26424007. 28. Aust MC, Fernandes D, Kolokythas P, Kaplan HM, Vogt PM. Percutaneous collagen induction therapy: an alternative treatment for scars, wrinkles, and skin laxity. Plast Reconstr Surg. 2008;121(4):1421-1429. DOI: 10.1097/01.prs.0000304612.72899.02. PMID: 18349665. 29. Maia Campos PMBG, Melo MO, Siqueira César FC. Topical application and oral supplementation of peptides in the improvement of skin viscoelasticity and density. J Cosmet Dermatol. 2019;18(6):1693-1699. DOI: 10.1111/jocd.12893. PMID: 30834689. 30. Byrne AJ, Al-Bader T, Kerrigan D, Hickey S, Laloeuf A, Rawlings AV. Synergistic action of a triple peptide complex on an essential extra-cellular matrix protein exhibits significant anti-aging benefits. Cosmet Dermatol. 2010;9(2):108-116. DOI: 10.1111/j.1473-2165.2010.00494.x. PMID: 20618556. 31. Ricard-Blum S. The collagen family. Cold Spring Harb Perspect Biol. 2011;3(1):a004978. DOI: 10.1101/cshperspect.a004978. PMID: 21421911. PMCID: PMC3003457. 32. Lephart ED. Equol’s anti-aging effects protect against environmental assaults by increasing skin antioxidant defense and ECM proteins while decreasing oxidative stress and inflammation. Cosmetics. 2018;5(1):16. DOI: 10.3390/cosmetics5010016 33. Bos JD, Meinardi MM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol. 2000;9(3):165-169. DOI: 10.1034/j.1600-0625.2000.009003165.x. PMID: 10839713. 34. Matsuda N, Koyama Y, Hosaka Y, et al. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J Nutr Sci Vitaminol (Tokyo). 2006;52(3):211-215. DOI: 10.3177/jnsv.52.211. PMID: 16967766. 35. Watanabe-Kamiyama M, Shimizu M, Kamiyama S, et al. Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. J Agric Food Chem. 2010;58(2):835-841. DOI: 10.1021/jf9031487. PMID: 19957932. 36. Tanaka M, Koyama Y, Nomura Y. Effects of collagen peptide ingestion on UV-B-induced skin damage. Biosci Biotechnol Biochem. 2009;73(4):930-932. DOI: 10.1271/bbb.80649. PMID: 19352014. 37. Matsumoto H. Clinical effects of fish type I collagen hydrolysate on skin properties. ITE Lett Batter New Technol Med. 2006;7:386–390. 38. Avila Rodríguez MI, Rodriguez Barroso LG, Sánchez ML. Collagen: A review on its sources and potential cosmetic applications. J Cosmet Dermatol. 2018;17(1):20-26. DOI: 10.1111/jocd.12450. PMID: 29144022. 39. Žmitek K, Žmitek J, Rogl Butina M, Pogačnik T. Effects of a combination of water-soluble coenzyme Q10 and collagen on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study. Nutrients. 2020;12(3):618. DOI: 10.3390/nu12030618. PMID: 32120787. PMCID: PMC7146335. 40. Sangsuwan W, Asawanonda P. Four-weeks daily intake of oral collagen hydrolysate results in improved skin elasticity, especially in sun-exposed areas: A randomized, double-blind, placebo-controlled trial. J Dermatolog Treat. 2021;32(8):991-996. DOI: 10.1080/09546634.2020.1725412. PMID: 32009486. 41. Bolke L, Schlippe G, Gerß J, Voss W. A collagen supplement improves skin hydration, elasticity, roughness, and density: Results of a randomized, placebo-controlled, blind study. Nutrients. 2019;11(10):2494. DOI: 10.3390/nu11102494. PMID: 31627309. PMCID: PMC6835901. 42. Asserin J, Lati E, Shioya T, Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015;14(4):291-301. DOI: 10.1111/jocd.12174. PMID: 26362110.

Send mail to Author


Send Cancel