Combination of Fractional CO2 Laser and Imiquimod in Pigmented Basal Cell Carcinoma: Preliminary Clinical Observations

Combination of Fractional CO2 Laser and Imiquimod in Pigmented Basal Cell Carcinoma: Preliminary Clinical Observations

Authors

  • Luca Ambrosio IDI-IRCCS, Dermatological Research Hospital, 00167 Rome, Italy
  • Giovanni Di Lella IDI-IRCCS, Dermatological Research Hospital, 00167 Rome, Italy
  • Caterina Longo Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy; Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Skin Cancer Center, Reggio Emilia, Italy
  • Giovanni Pellacani Dermatology Unit, Department of Clinical Internal Anesthesiologic Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy
  • Iris Zalaudek Department of Dermatology, Maggiore Hospital, University of Trieste, Trieste, Italy
  • Claudio Conforti IDI-IRCCS, Dermatological Research Hospital, 00167 Rome, Italy

Keywords:

Pigmented Basal Cell Carcinoma, Fractional CO2 Laser, Imiquimod, Combination Therapy, Preliminary Clinical Outcomes

References

Peris K, Fargnoli MC, Kaufmann R, et al. European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma-update 2023. Eur J Cancer. 2023 Oct;192:113254. DOI: 10.1016/j.ejca.2023.113254

Omland SH, Wenande EC, Svane IM, Tam J, Olesen UH, Hædersdal M. Laser immunotherapy: A potential treatment modality for keratinocyte carcinoma. Vol. 13, Cancers. 2021; 13(21):5405. DOI: 10.3390/cancers13215405

Apalla Z, Lallas A, Tzellos T, et al. Applicability of dermoscopy for evaluation of patients’ response to nonablative therapies for the treatment of superficial basal cell carcinoma. Br J Dermatol. 2014 Apr;170(4):809–15. DOI: 10.1111/bjd.12749

Alma A, Pongetti L, Clementi A, et al. Combined Carbon Dioxide Laser with Photodynamic Therapy for Nodular Basal Cell Carcinoma Monitored by Reflectance Confocal Microscopy. Medicina (Lithuania). 2024 Jan 1;60(1). DOI: 10.3390/medicina60010030

Navarrete-Dechent C, Cordova M, Aleissa S, et al. Reflectance confocal microscopy confirms residual basal cell carcinoma on clinically negative biopsy sites before Mohs micrographic surgery: A prospective study. J Am Acad Dermatol. 2019 Aug;81(2):417–26. DOI: 10.1016/j.jaad.2019.02.049

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Published

2025-10-31

Issue

Vol. 15 No. 4 (2025): 2025 Vol 15, No 4 | October

Section

Research Letter

License

Copyright (c) 2025 Luca Ambrosio, Giovanni Di Lella, Caterina Longo, Giovanni Pellacani, Iris Zalaudek, Claudio Conforti

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Dermatology Practical & Conceptual applies a Creative Commons Attribution License (CCAL) to all works we publish (http://creativecommons.org/licenses/by-nc/4.0/). Authors retain the copyright for their published work.

How to Cite

1.
Ambrosio L, Di Lella G, Longo C, Pellacani G, Zalaudek I, Conforti C. Combination of Fractional CO2 Laser and Imiquimod in Pigmented Basal Cell Carcinoma: Preliminary Clinical Observations. Dermatol Pract Concept. 2025;15(4):5586. doi:10.5826/dpc.1504a5586

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